1-(3,4-dichlorophenyl)cyclopentane-1-carboxylic acid

Base Information

• Chemical Name: 1-(3,4-dichlorophenyl)cyclopentane-1-carboxylic acid
• CAS No.: 437650-06-1
• Molecular Formula: C12H12Cl2O2
• Molecular Weight: 259.13
• Mol file: 437650-06-1.mol

Synonyms:Chembrdg-BB 6644827; 1-(3,4-DICHLOROPHENYL)-CYCLOPENTANECARBOXYLIC ACID; 1-(3,4-Dichlorophenyl)cyclopentanecarboxylic acid;

Chemical Property of 1-(3,4-dichlorophenyl)cyclopentane-1-carboxylic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3,4-dichlorophenyl)cyclopentane-1-carboxylic acid

There total 2 articles about 1-(3,4-dichlorophenyl)cyclopentane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(3,4-dichlorophenyl)cyclopentane-1-carbonitrile (213755-91-0) → 1-(3,4-dichlorophenyl)cyclopentanecarboxylic acid (437650-06-1)

Guidance literature:

With potassium hydroxide; In ethylene glycol; for 10h; Heating;

DOI:10.1023/A:1013728105186

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → 1-(3,4-dichlorophenyl)cyclopentanecarboxylic acid (437650-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / NaOH / 12 h / 120 °C

2: 82 percent / KOH / ethane-1,2-diol / 10 h / Heating

With potassium hydroxide; sodium hydroxide; In ethylene glycol;

DOI:10.1023/A:1013728105186

Reference yield:

1-(3,4-dichlorophenyl)cyclopentanecarboxylic acid (437650-06-1) → 1-(3,4-dichloro-phenyl)-cyclopentanecarbonyl chloride (437650-08-3)

Guidance literature:

With thionyl chloride; In benzene; for 8h; Heating;

DOI:10.1023/A:1013728105186

upstream raw materials:

1-(3,4-dichlorophenyl)cyclopentane-1-carbonitrile

3,4-dichloro-benzeneacetonitrile

Downstream raw materials:

1-(3,4-dichloro-phenyl)-cyclopentanecarbonyl chloride