5-iodo-2-methyl-2H-indazole

Base Information

• Chemical Name: 5-iodo-2-methyl-2H-indazole
• CAS No.: 1150617-94-9
• Molecular Formula: C8H7IN2
• Molecular Weight: 258.06
• Mol file: 1150617-94-9.mol

Synonyms:5-iodo-2-methyl-2H-indazole;QC-5137;2H-INDAZOLE,5-IODO-2-METHYL;

Chemical Property of 5-iodo-2-methyl-2H-indazole

Chemical Property:

• PSA: 17.82000
• LogP: 2.17790
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Iodo-2-methyl-2H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-iodo-2-methyl-2H-indazole

There total 4 articles about 5-iodo-2-methyl-2H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

5-iodo-1H-indazole (55919-82-9) + trimethoxonium tetrafluoroborate (420-37-1) → 5-iodo-2-methyl-2H-indazole (1150617-94-9)

Guidance literature:

5-iodo-1H-indazole; trimethoxonium tetrafluoroborate; In ethyl acetate; at 20 ℃; for 2h;

With sodium hydroxide; In water; ethyl acetate; pH=12; Cooling with ice;

Reference yield:

5-nitroindazole (5401-94-5) → 5-iodo-2-methyl-2H-indazole (1150617-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 25 °C / Autoclave; Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

2.2: 1.5 h / 10 - 50 °C

2.3: pH 8

3.1: ethyl acetate / 2 h / 20 °C

3.2: pH 12 / Cooling with ice

With hydrogenchloride; hydrogen; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

1H-indazol-5-ylamine (19335-11-6) → 5-iodo-2-methyl-2H-indazole (1150617-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

1.2: 1.5 h / 10 - 50 °C

1.3: pH 8

2.1: ethyl acetate / 2 h / 20 °C

2.2: pH 12 / Cooling with ice

With hydrogenchloride; sodium nitrite; In water; ethyl acetate;

upstream raw materials:

5-nitroindazole

1H-indazol-5-ylamine

5-iodo-1H-indazole

trimethoxonium tetrafluoroborate

Downstream raw materials:

6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine

Refernces

• 1、 -. "COMPOUND USEFUL AS A C-MET INHIBITOR". . . Retrieved 2012/02/06.