c-Met inhibitor 1

Base Information

Chemical Name:c-Met inhibitor 1
CAS No.:1357072-61-7
Molecular Formula:C17H14N8S
Molecular Weight:362.41166
Hs Code.:
Mol file:1357072-61-7.mol

Synonyms:c-Met inhibitor 1;6-(1-METHYL-1H-PYRAZOL-4-YL)-3-((2-METHYL-2H-INDAZOL-5-YL)THIO)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE;3-[(2-Methyl-2H-indazol-5-yl)thio]-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazine;c-Met inhibitor

Suppliers and Price of c-Met inhibitor 1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
c-Metinhibitor1 >98%
1 g
$ 2000.00

DC Chemicals
c-Metinhibitor1 >98%
100 mg
$ 500.00

Crysdot
c-Metinhibitor1 98+%
10mg
$ 381.00

Crysdot
c-Metinhibitor1 98+%
100mg
$ 1638.00

Crysdot
c-Metinhibitor1 98+%
5mg
$ 297.00

Crysdot
c-Metinhibitor1 98+%
50mg
$ 1028.00

ChemScene
c-Metinhibitor1 98.01%
50mg
$ 800.00

ChemScene
c-Metinhibitor1 98.01%
5mg
$ 220.00

ChemScene
c-Metinhibitor1 98.01%
10mg
$ 300.00

ChemScene
c-Metinhibitor1 98.01%
100mg
$ 1350.00

Total 7 raw suppliers

Chemical Property of c-Met inhibitor 1

Chemical Property:

PKA:-0.27±0.30(Predicted)
PSA：104.02000
Density:1.55±0.1 g/cm3(Predicted)
LogP:2.56270

Purity/Quality:

97% ^*data from raw suppliers

c-Metinhibitor1 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of c-Met inhibitor 1

There total 5 articles about c-Met inhibitor 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

: 1022151-55-8
6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine-3-thiol

: 1150617-94-9
5-iodo-2-methyl-2H-indazole

: 1357072-61-7
6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: With caesium carbonate; 2-Picolinic acid; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 10h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 5401-94-5
5-nitroindazole

: 1357072-61-7
6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 25 °C / Autoclave; Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

2.2: 1.5 h / 10 - 50 °C

2.3: pH 8

3.1: ethyl acetate / 2 h / 20 °C

3.2: pH 12 / Cooling with ice

4.1: caesium carbonate / copper(l) iodide; 2-Picolinic acid / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere

With hydrogenchloride; hydrogen; caesium carbonate; sodium nitrite; 2-Picolinic acid; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 943541-20-6
3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

: 1357072-61-7
6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 18 h / 4 °C / Reflux

2: potassium hydroxide / ethanol; water / 3 h / 60 - 67 °C / Inert atmosphere

3: caesium carbonate / copper(l) iodide; 2-Picolinic acid / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere

With caesium carbonate; hydrazine hydrate; potassium hydroxide; 2-Picolinic acid; copper(l) iodide; In ethanol; water; N,N-dimethyl-formamide;