c-Met inhibitor 1

Base Information

• Chemical Name: c-Met inhibitor 1
• CAS No.: 1357072-61-7
• Molecular Formula: C17H14N8S
• Molecular Weight: 362.41166
• Mol file: 1357072-61-7.mol

Synonyms:c-Met inhibitor 1;6-(1-METHYL-1H-PYRAZOL-4-YL)-3-((2-METHYL-2H-INDAZOL-5-YL)THIO)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE;3-[(2-Methyl-2H-indazol-5-yl)thio]-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazine;c-Met inhibitor

Chemical Property of c-Met inhibitor 1

Chemical Property:

• PKA: -0.27±0.30(Predicted)
• PSA: 104.02000
• Density: 1.55±0.1 g/cm3(Predicted)
• LogP: 2.56270

Purity/Quality:

99%+, ^*data from raw suppliers

c-Metinhibitor1 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of c-Met inhibitor 1

There total 5 articles about c-Met inhibitor 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine-3-thiol (1022151-55-8) + 5-iodo-2-methyl-2H-indazole (1150617-94-9) → 6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine (1357072-61-7)

Guidance literature:

With caesium carbonate; 2-Picolinic acid; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 10h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

5-nitroindazole (5401-94-5) → 6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine (1357072-61-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 25 °C / Autoclave; Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

2.2: 1.5 h / 10 - 50 °C

2.3: pH 8

3.1: ethyl acetate / 2 h / 20 °C

3.2: pH 12 / Cooling with ice

4.1: caesium carbonate / copper(l) iodide; 2-Picolinic acid / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere

With hydrogenchloride; hydrogen; caesium carbonate; sodium nitrite; 2-Picolinic acid; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (943541-20-6) → 6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine (1357072-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 18 h / 4 °C / Reflux

2: potassium hydroxide / ethanol; water / 3 h / 60 - 67 °C / Inert atmosphere

3: caesium carbonate / copper(l) iodide; 2-Picolinic acid / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere

With caesium carbonate; hydrazine hydrate; potassium hydroxide; 2-Picolinic acid; copper(l) iodide; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

5-nitroindazole

3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

3-hydrazinyl-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

1H-indazol-5-ylamine

Refernces