(2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride

Base Information

Chemical Name:(2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride
CAS No.:794460-89-2
Molecular Formula:C11H20N4O
Molecular Weight:224.30
Hs Code.:
Mol file:794460-89-2.mol

Synonyms:2-Pyrrolidinecarbonitrile, 1-[[(2-amino-1,1-dimethylethyl)amino]acetyl]-, (2S)- (9CI);

Suppliers and Price of (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride

There total 3 articles about (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 739365-95-8
tert-butyl N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]carbamate

: 794460-89-2
(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1h; Cooling with ice;
DOI:10.1016/j.bmc.2011.09.043

Reference yield: 85.0%

: C₂₄H₂₈N₄O

: 794460-89-2
(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

Reference yield:

: 207557-35-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

: 794460-89-2
(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / acetone / 20 °C / Cooling with ice

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; potassium carbonate; sodium iodide; In 1,4-dioxane; dichloromethane; acetone;
DOI:10.1016/j.bmc.2011.09.043