(S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride

Base Information

• Chemical Name: (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride
• CAS No.: 1359669-09-2
• Molecular Formula: C₂₆H₃₁N₇O₂*ClH
• Molecular Weight: 510.039
• Mol file: 1359669-09-2.mol

Synonyms:(S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride

Chemical Property of (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride

There total 6 articles about (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile (794460-89-2) + C19H15N5O3 → (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride (1359669-09-2)

Guidance literature:

(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile; C₁₉H₁₅N₅O₃; With triethylamine; In tetrahydrofuran; at 20 ℃; Cooling with ice;

With hydrogenchloride; In 1,4-dioxane; water; at 10 ℃; for 0.166667h;

DOI:10.1016/j.bmc.2011.09.043

Reference yield:

5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (739364-98-8) → (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride (1359669-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice

2.2: 0.17 h / 10 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmc.2011.09.043

Reference yield:

3(5)-phenylpyrazol-5(3)-amine (1572-10-7) → (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride (1359669-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / 3 h / 120 °C

1.2: 1 h / 70 °C

1.3: 20 °C

2.1: tetrahydrofuran / 4 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice

3.2: 0.17 h / 10 °C

With acetic acid; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmc.2011.09.043

upstream raw materials:

tert-butyl N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]carbamate

(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile

5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid

3⁽⁵⁾-phenylpyrazol-5⁽³⁾-amine

Refernces