4-Methoxypyrimidin-5-ylboronicacid

Base Information

• Chemical Name: 4-Methoxypyrimidin-5-ylboronicacid
• CAS No.: 909187-37-7
• Molecular Formula: C5H7BN2O3
• Molecular Weight: 153.933
• Mol file: 909187-37-7.mol

Synonyms:4-methoxy-5-pyrimidineboronic acid;4-methoxypyrimidin-5-ylboronic acid;D-5127;

Chemical Property of 4-Methoxypyrimidin-5-ylboronicacid

Chemical Property:

• PSA: 75.47000
• LogP: -1.83500

Purity/Quality:

98%min ^*data from raw suppliers

(4-Methoxypyrimidin-5-yl)boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (4-Methoxypyrimidin-5-yl)boronic Acid is a boronic acid derivative and is potentially useful in Suzuki-Miyaura cross-coupling reaction for the palladium catalyzed formation of carbon-carbon bonds. (4-Methoxypyrimidin-5-yl)boronic Acid s a boronic acid derivative and is potentially useful in Suzuki-Miyaura cross-coupling reaction for the palladium catalyzed formation of carbon-carbon bonds.

Technology Process of 4-Methoxypyrimidin-5-ylboronicacid

There total 2 articles about 4-Methoxypyrimidin-5-ylboronicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

→ (4-methoxypyrimidin-5-yl)boronic acid (909187-37-7)

Guidance literature:

With isopropylmagnesium bromide; In tetrahydrofuran; for 0.5h;

In tetrahydrofuran; for 1h; Cooling with ice;

Reference yield:

5-bromo-4-methoxy-pyrimidine (4319-85-1) → (4-methoxypyrimidin-5-yl)boronic acid (909187-37-7)

Guidance literature:

With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -70 - -20 ℃; for 0.5h;

Reference yield: 78.0%

(4-methoxypyrimidin-5-yl)boronic acid (909187-37-7) + 7-{[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]methyl}-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine → 7-{[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]methyl}-5-(4-methoxypyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In water; acetonitrile; at 70 ℃; for 6h;

upstream raw materials:

5-bromo-4-methoxy-pyrimidine

Downstream raw materials:

N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(4-methoxypyrimidin 5-yl)quinoline-3-sulfonamide

3-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-5-(4-methoxypyrimidin-5-yl)pyridin-2-amine

5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(4-methoxy-pyrimidin-5-yl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Refernces

• 1、 -. "PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF". Paragraph 0454. . Retrieved 2018/10/24.
• 2、 -. "Phthalazine, aza- and diaza-phthalazine compounds and methods of use". Page/Page column 49. . Retrieved 2008/06/13.