4319-85-1

Basic information

• Product Name: 5-BroMo-4-MethoxypyriMidine
• Synonyms: 5-BroMo-4-MethoxypyriMidine
• CAS NO: 4319-85-1
• Molecular Formula: C5H5BrN2O
• Molecular Weight: 189.01
• EINECS: 604-604-1
• Mol File: 4319-85-1.mol

Chemical Properties

• Melting Point: 72-74 °C
• Boiling Point: 243.5±20.0 °C(Predicted)
• Appearance: /
• Density: 1.628±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.50±0.16(Predicted)
• CAS DataBase Reference: 5-BroMo-4-MethoxypyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-4-MethoxypyriMidine(4319-85-1)
• EPA Substance Registry System: 5-BroMo-4-MethoxypyriMidine(4319-85-1)

Safety Data

• Hazardous Substances Data: 4319-85-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-4-methoxypyrimidine is used as a key intermediate in the synthesis of various drugs for the treatment of different diseases. Its unique chemical structure allows for the development of compounds with specific therapeutic properties, making it a valuable building block in the pharmaceutical sector.
Used in Agrochemical Industry:
In the field of agrochemicals, 5-Bromo-4-methoxypyrimidine is utilized as a precursor in the production of crop protection agents. Its incorporation into these compounds helps in the development of effective solutions for pest control and disease management, contributing to improved crop yields and food security.
Overall, 5-Bromo-4-methoxypyrimidine is a versatile chemical compound with significant applications in both the pharmaceutical and agrochemical industries, playing a vital role in the synthesis of life-saving drugs and crop protection agents.

Upstream product

• 67-56-1 methanol 
• 56181-39-6 4-chloro-5-bromopyrimidine 
• 124-41-4 sodium methylate 
• 19808-30-1 5-bromo-4(3H)-pyrimidinone 

Downstream Products

• 130532-90-0 5-bromo-α-phenyl-4-pyrimidineacetonitrile 
• 84332-00-3 methyl 4-methoxypyrimidine-5-carboxylate 
• 19808-30-1 5-bromo-4(3H)-pyrimidinone 
• 1448866-87-2 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-2-(4-methoxy-pyrimidin-5-yl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-67-8 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-2-(4-methoxy-pyrimidin-5-yl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1445879-74-2 N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(4-methoxypyrimidin 5-yl)quinoline-3-sulfonamide 
• 909187-37-7 (4-methoxypyrimidin-5-yl)boronic acid 

Relevant articles and documents

PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF

PROBLEM TO BE SOLVED: To provide compounds with excellent antimycotic activity against Trichophyton. SOLUTION: The invention provides pharmaceuticals comprising biaryl derivatives represented by general formula (I) or salts thereof, where ring A is optionally substituted phenyl or the like; Q is CH2 or the like; X1, X2 and X3 are CR1 or the like; and Y is CH or N. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME

Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.

PYRROLOPYRROLIDINONE COMPOUNDS

The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

Phthalazine, aza- and diaza-phthalazine compounds and methods of use

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.