3-bromo-5-chloropyridine-2-carbonitrile

Base Information

• Chemical Name: 3-bromo-5-chloropyridine-2-carbonitrile
• CAS No.: 760207-83-8
• Molecular Formula: C6H2BrClN2
• Molecular Weight: 217.453
• Hs Code.: 2933399090
• Mol file: 760207-83-8.mol

Synonyms:3-bromo-5-chloropyridine-2-carbonitrile;3-Bromo-5-chloro-2-cyanopyridine;3-broMo-2-cyano-5-chloropyridine;

Chemical Property of 3-bromo-5-chloropyridine-2-carbonitrile

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 297.491°C at 760 mmHg
• PKA: -4.96±0.20(Predicted)
• Flash Point: 133.718°C
• PSA: 36.68000
• Density: 1.854g/cm³
• LogP: 2.36918
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

3-Bromo-5-chloropyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromo-5-chloropyridine-2-carbonitrile

There total 2 articles about 3-bromo-5-chloropyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

copper(l) cyanide + 2,3-dibromo-5-chloro-pyridine (137628-17-2) → 3-bromo-5-chloropyridine-2-carbonitrile (760207-83-8)

Guidance literature:

In propiononitrile; at 150 ℃; for 2.5h; Microwave irradiation;

Reference yield:

copper(l) cyanide + 2,3-dibromo-5-chloro-pyridine (137628-17-2) + propiononitrile (107-12-0) → 3-bromo-5-chloropyridine-2-carbonitrile (760207-83-8)

Guidance literature:

Reference yield:

3-bromo-5-chloropyridine-2-carbonitrile (760207-83-8) + trimethyl-[2-(3,4,5-trifluorophenyl)ethynyl]silane + acetyl 2,4,6-tri-O-acetyl-3-azido-3-deoxy-1-thio-α-D-galactopyranoside → 5-chloro-2-cyano-3-pyridyl 2,4,6-tri-O-acetyl-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-α-D-galactopyranoside + 5-bromo-6-cyano-3-pyridyl 2,4,6-tri-O-acetyl-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-α-D-galactopyranoside

Guidance literature:

3-bromo-5-chloropyridine-2-carbonitrile; acetyl 2,4,6-tri-O-acetyl-3-azido-3-deoxy-1-thio-α-D-galactopyranoside; With diethylamine; In dichloromethane; at 20 ℃; for 20h;

trimethyl-[2-(3,4,5-trifluorophenyl)ethynyl]silane; With copper(l) iodide; triethylamine; cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Overall yield = 50 mg; Inert atmosphere;

upstream raw materials:

2,3-dibromo-5-chloro-pyridine

propiononitrile

Downstream raw materials:

(3R)-5-amino-3-(5-((3-chloro-5-fluoro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

(3R,6R)-5-Amino-3-(5-((3-chloro-5-fluoro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

(R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

(R)-5-amino-3-(5-((3-chloro-5-vinyl-1,7-naphthyridin-8-yl)-amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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