(R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Base Information

Chemical Name:(R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide
CAS No.:1600508-52-8
Molecular Formula:C₂₁H₂₀BrClFN₅O₂S
Molecular Weight:540.844
Hs Code.:

Synonyms:(R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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Chemical Property of (R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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Technology Process of (R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

There total 11 articles about (R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (R)-tert-butyl (5-(5-amino-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate

: 1600513-24-3
5-bromo-3,8-dichloro-1,7-naphthyridine

: 1600508-52-8
(R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: With sulfuric acid; In ethyl acetate; isopropyl alcohol;

Reference yield:

: 1600512-90-0
5-bromo-3-chloro-1,7-naphthyridin-8(7H)-one

: 1600508-52-8
(R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate

2: sulfuric acid / ethyl acetate; isopropyl alcohol

With sulfuric acid; trichlorophosphate; In ethyl acetate; isopropyl alcohol;

Reference yield:

: 1600511-35-0
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)thio)propan-2-yl)carbamate

: 1600508-52-8
(R)-5-amino-3-(5-((5-bromo-3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / methanol; dihydrogen peroxide; N,N-dimethyl-formamide; ethyl acetate

2: hydrogenchloride / 1,4-dioxane

3: sodium hydrogencarbonate / 1,4-dioxane

4: sodium azide / water; ethanol

5: water; tetrahydrofuran

6: sulfuric acid / ethyl acetate; isopropyl alcohol

With hydrogenchloride; sodium azide; sulfuric acid; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dihydrogen peroxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;