Thiazole, 2-iodo-4-(trifluoromethyl)-

Base Information

• Chemical Name: Thiazole, 2-iodo-4-(trifluoromethyl)-
• CAS No.: 864376-14-7
• Molecular Formula: C4HF3INS
• Molecular Weight: 279.0221196
• Mol file: 864376-14-7.mol

Synonyms:2-iodo-4-(trifluoromethyl)Thiazole;2-iodo-4-trifluoromethylthiazole;

Chemical Property of Thiazole, 2-iodo-4-(trifluoromethyl)-

Chemical Property:

• PSA: 41.13000
• LogP: 2.76650

Purity/Quality:

98%min ^*data from raw suppliers

2-Iodo-4-(trifluoromethyl)-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiazole, 2-iodo-4-(trifluoromethyl)-

There total 2 articles about Thiazole, 2-iodo-4-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(trifluoromethyl)-1,3-thiazol-2-amine (349-49-5) → 2-iodo-4-trifluoromethyl-thiazole (864376-14-7)

Guidance literature:

With copper(l) iodide; tert.-butylnitrite; In acetonitrile; at 0 ℃; for 2h;

Reference yield:

→ 2-iodo-4-trifluoromethyl-thiazole (864376-14-7)

Guidance literature:

Reference yield: 57.0%

2-iodo-4-trifluoromethyl-thiazole (864376-14-7) + C22H19F7N2O → 2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-2-((1R,5S)-10-(4-(trifluoromethyl)thiazol-2-yl)-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-yl)propenamide

Guidance literature:

With 6-methyl-2-pyridinecarboxylic acid; palladium diacetate; cesium pivalate; In tert-Amyl alcohol; at 130 ℃; Sealed tube;

DOI:10.1021/acs.joc.0c00870

upstream raw materials:

4-(trifluoromethyl)-1,3-thiazol-2-amine

Refernces

• 1、 -. "THIAZOLE DERIVATIVE". Page/Page column 43. . Retrieved 2010/11/24.