2-BroMo-4-(trifluoroMethyl)thiazole

Base Information

• Chemical Name: 2-BroMo-4-(trifluoroMethyl)thiazole
• CAS No.: 41731-39-9
• Molecular Formula: C4HBrF3NS
• Molecular Weight: 232.024
• Hs Code.: 2934100090
• Mol file: 41731-39-9.mol

Synonyms:2-BroMo-4-(trifluoroMethyl)thiazole;Thiazole, 2-broMo-4-(trifluoroMethyl)-;

Chemical Property of 2-BroMo-4-(trifluoroMethyl)thiazole

Chemical Property:

• Boiling Point: 182.8±35.0 °C(Predicted)
• PKA: -2.20±0.10(Predicted)
• PSA: 41.13000
• Density: 1.904±0.06 g/cm3(Predicted)
• LogP: 2.92440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-bromo-4-(trifluoromethyl)thiazole 97+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-4-(trifluoroMethyl)thiazole

There total 1 articles about 2-BroMo-4-(trifluoroMethyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

4-(trifluoromethyl)-1,3-thiazol-2-amine (349-49-5) → 2-bromo-4-(trifluoromethyl)thiazole (41731-39-9)

Guidance literature:

With tert.-butylnitrite; copper(I) bromide; In acetonitrile; at 70 ℃; for 3h;

Reference yield: 85.0%

2-bromo-4-(trifluoromethyl)thiazole (41731-39-9) + (2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-methyl-1-((R)-piperidin-3-ylmethyl)piperidine → 4-(trifluoromethyl)-2-((S)-3-(((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-methylpiperidin-1-yl)methyl)piperidin-1-yl)thiazole

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; at 100 ℃; for 18h; Inert atmosphere;

Reference yield: 66.0%

2-bromo-4-(trifluoromethyl)thiazole (41731-39-9) + (3S,4R,5R)-3,4,5-tris(benzyloxy)-1-((R)-piperidin-3-ylmethyl)piperidine → 4-(trifluoromethyl)-2-((S)-3-(((3S,4S,5R)-3,4,5-tris(benzyloxy)piperidin-1-yl)methyl)piperidin-1-yl)thiazole

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; ruphos; In toluene; at 100 ℃; for 16h; Inert atmosphere; Sealed tube;

upstream raw materials:

4-(trifluoromethyl)-1,3-thiazol-2-amine

Downstream raw materials:

4-(trifluoromethyl)thiazole-2-carbonitrile

4-methyl-2-tributylstannanyl-thiazole

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