2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone

Base Information

• Chemical Name: 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
• CAS No.: 864445-43-2
• Molecular Formula: C₂₂H₂₅NO₂
• Molecular Weight: 335.446
• Hs Code.: 2933990057
• Mol file: 864445-43-2.mol

Synonyms:2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone

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Chemical Property of 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone

Chemical Property:

• PSA: 31.23000
• Density: 1.06
• LogP: 5.26550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A new class of cannabimimetic indoles.

Technology Process of 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone

There total 5 articles about 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-Bromopentane (110-53-2) + 1-(1H-indol-3-yl)-2-(2-methoxyphenyl)ethanone (1097087-10-9) + ethyl 4-(3-(1-naphthoyl)-2-methyl-1H-indol-1-yl) butanoate (1427325-10-7) → JWH 250 (864445-43-2)

Guidance literature:

In dichloromethane; water; mineral oil;

Reference yield:

1-pentyl-1H-indole (59529-21-4) + 2-(2-methoxyphenyl)acetyl chloride (28033-63-8) → JWH 250 (864445-43-2)

Guidance literature:

1-pentyl-1H-indole; With dimethylaluminum chloride; In dichloromethane; at 0 ℃;

2-(2-methoxyphenyl)acetyl chloride; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmcl.2005.06.008

Reference yield:

2-Methoxybenzoyl chloride (21615-34-9) → JWH 250 (864445-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thiophen-2-yl magnesium bromide; ammonium chloride / diethyl ether

2: mineral oil; water; dichloromethane

With ammonium chloride; thiophen-2-yl magnesium bromide; In diethyl ether; dichloromethane; water; mineral oil;

upstream raw materials:

1-pentyl-1H-indole

2-(2-methoxyphenyl)acetyl chloride

2-Methoxybenzoyl chloride

indole