4-AMINOTHIAZOLE Hydrochloride

Base Information

• Chemical Name: 4-AMINOTHIAZOLE Hydrochloride
• CAS No.: 59134-95-1
• Molecular Formula: C3H4N2S.HCl
• Molecular Weight: 136.605
• Hs Code.: 2934100090
• Mol file: 59134-95-1.mol

Synonyms:Thiazol-4-aMine HCl;4-Thiazolamine, hydrochloride;

Chemical Property of 4-AMINOTHIAZOLE Hydrochloride

Chemical Property:

• PSA: 67.15000
• LogP: 2.10850
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Thiazol-4-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Thiazolamine Hydrochloride, is an isomer of 2-Aminothiazole (A630415), which is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds, including sulfur drugs, biocides, fungicides, and dyes.

Technology Process of 4-AMINOTHIAZOLE Hydrochloride

There total 1 articles about 4-AMINOTHIAZOLE Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiazol-4-ylaminocarboxylic acid tert-butyl ester (1235406-42-4) → thiazol-4-amine hydrochloride (59134-95-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; water; at 20 ℃; for 3h;

Reference yield: 38.7%

thiazol-4-amine hydrochloride (59134-95-1) + acetic anhydride (108-24-7) → N-(thiazol-4-yl)acetamide (7041-83-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 34.0%

thiazol-4-amine hydrochloride (59134-95-1) + perfluorophenyl 4-(2-cyano-4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate (1450923-35-9) → 4-(2-cyano-4-(trifluoromethyl)phenyl)-N-(thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (1450921-69-3)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; for 3h; Cooling with acetone-dry ice;

upstream raw materials:

thiazol-4-ylaminocarboxylic acid tert-butyl ester

Downstream raw materials:

4-(2-cyano-4-(trifluoromethyl)phenyl)-N-(thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

N-(thiazol-4-yl)acetamide

Refernces

• 1、 -. "HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS". Paragraph 0871; 0873; 0874. . Retrieved 2020/03/23.