3-Iodo-4,7-diazaindole

Base Information

• Chemical Name: 3-Iodo-4,7-diazaindole
• CAS No.: 889451-26-7
• Molecular Formula: C6H4IN3
• Molecular Weight: 245.022
• Mol file: 889451-26-7.mol

Synonyms:3-Iodo-4,7-diazaindole

Chemical Property of 3-Iodo-4,7-diazaindole

Chemical Property:

• PSA: 41.57000
• LogP: 1.56250

Purity/Quality:

97% ^*data from raw suppliers

3-Iodo-4,7-diazaindole 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Iodo-4,7-diazaindole

There total 1 articles about 3-Iodo-4,7-diazaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

pyrrolo<2,3-b>pyrazine (4745-93-1) → 7-iodo-5H-pyrrolo[2,3-b]pyrazine (889451-26-7)

Guidance literature:

With N-iodo-succinimide; In 2-methyltetrahydrofuran; at 20 ℃;

Reference yield: 83.0%

7-iodo-5H-pyrrolo[2,3-b]pyrazine (889451-26-7) + trityl chloride (76-83-5) → 7-iodo-5-trityl-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

7-iodo-5H-pyrrolo[2,3-b]pyrazine (889451-26-7) → 7-(1-benzyl-1H-1,2,3-triazol-4-yl)-5H-pyrrolo-[2,3-b]pyrazine (1316228-57-5)

Guidance literature:

Multi-step reaction with 5 steps

1: dmap / dichloromethane / 1 h / 20 °C

2: copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

4: tetrahydrofuran; methanol / 48 h / 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 1 h / 20 °C

With dmap; copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 2: Sonogashira coupling;

DOI:10.1039/c1ob05586k

upstream raw materials:

pyrrolo<2,3-b>pyrazine

Downstream raw materials:

7-(1-benzyl-1H-1,2,3-triazol-4-yl)-5H-pyrrolo-[2,3-b]pyrazine

tert-butyl 7-(1-benzyltriazol-4-yl)pyrrolo[2,3-b]pyrazine-5-carboxylate