VX-770

Base Information

• Chemical Name: VX-770
• CAS No.: 1174930-71-2
• Molecular Formula: C24H28N2O3
• Molecular Weight: 392.49072
• Mol file: 1174930-71-2.mol

Synonyms:

Chemical Property of VX-770

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Technology Process of VX-770

There total 58 articles about VX-770 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C24H27ClN2O2 → ivacaftor (873054-44-5,1174930-71-2)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 75 - 85 ℃; for 6h;

Reference yield: 87.0%

C24H27BrN2O2 → ivacaftor (873054-44-5,1174930-71-2)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 75 - 85 ℃; for 6h;

Reference yield: 80.0%

C31H34N2O3 → ivacaftor (873054-44-5,1174930-71-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 35 ℃; for 5h; under 1520.1 Torr; Temperature; Pressure;

upstream raw materials:

5-amino-2-4-di-tert-butyl-phenol

2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate

3-methyl-4-nitro-1H-indole

5-amino-2,4-di-tert-butylphenyl methyl carbonate

Downstream raw materials:

N-(2-(tert-butyl)-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

2-(5-tert-butyl-2-hydroxy-4-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl)-2-methylpropanoic acid

N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide propylene glycol solvate

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