(S)-methyl 2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-4-methylpentanoate

Base Information

• Chemical Name: (S)-methyl 2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-4-methylpentanoate
• CAS No.: 1191997-63-3
• Molecular Formula: C17H20ClNO4
• Molecular Weight: 337.803
• Mol file: 1191997-63-3.mol

Synonyms:(alphaS)-4-(2-Chlorophenoxy)-2,5-dihydro-alpha-(2-methylpropyl)-2-oxo-1H-pyrrole-1-acetic acid methyl ester;

Chemical Property of (S)-methyl 2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-4-methylpentanoate

Chemical Property:

• PSA: 55.84000
• Density: 1.246±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 2.97050

Purity/Quality:

99.3% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-methyl 2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-4-methylpentanoate

There total 7 articles about (S)-methyl 2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl (L)-leucinate hydrochloride (7517-19-3) + C11H10Cl2O3 → (S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester (1191997-63-3)

Guidance literature:

methyl (L)-leucinate hydrochloride; With triethylamine; In acetonitrile; at 60 ℃; for 1h;

C₁₁H₁₀Cl₂O₃; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 15h; Inert atmosphere;

Reference yield: 62.0%

methyl (L)-leucinate hydrochloride (7517-19-3) + C12H12BrClO3 → (S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester (1191997-63-3)

Guidance literature:

methyl (L)-leucinate hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 2h; Inert atmosphere;

C₁₂H₁₂BrClO₃; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 - 100 ℃; for 20h;

Reference yield: 57.0%

(E)-4-bromo-3-(2-chloro-phenoxy)-but-2-enoic acid ethyl ester (1191997-60-0) + methyl (L)-leucinate hydrochloride (7517-19-3) → (S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester (1191997-63-3)

Guidance literature:

methyl (L)-leucinate hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 - 105 ℃;

(E)-ethyl-4-bromo-3-(2-chlorophenoxy)-2-butenoate; In acetonitrile; at 105 ℃; Product distribution / selectivity;

upstream raw materials:

(E)-4-bromo-3-(2-chloro-phenoxy)-but-2-enoic acid ethyl ester

methyl (L)-leucinate hydrochloride

2-monochlorophenol

ethyl (2E)-3-(2-chlorophenoxy)but-2-enoate

Downstream raw materials:

(S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid

Refernces

• 1、 -. "Pyrrolidinone derivative as glucokinase activator and preparation method and application thereof". Paragraph 0129-0130; 0141-0142. . Retrieved 2021/10/13.