quinuclidin-4-ylMethanaMine

Base Information

• Chemical Name: quinuclidin-4-ylMethanaMine
• CAS No.: 67496-78-0
• Molecular Formula: 140.22604
• Molecular Weight: 140.228
• Hs Code.: 2933990090
• Mol file: 67496-78-0.mol

Synonyms:1-Azabicyclo[2.2.2]octane-4-methanamine;4-Aminomethylquinuclidine;

Chemical Property of quinuclidin-4-ylMethanaMine

Chemical Property:

• Boiling Point: 186℃
• PKA: 10.67±0.10(Predicted)
• Flash Point: 63℃
• PSA: 29.26000
• Density: 1.04
• LogP: 1.06920
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

95%, ^*data from raw suppliers

Quinuclidin-4-ylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of quinuclidin-4-ylMethanaMine

There total 2 articles about quinuclidin-4-ylMethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-cyanoquinuclidine (26458-78-6) → 4-aminomethylquinuclidine (67496-78-0)

Guidance literature:

4-cyanoquinuclidine; With lithium aluminium tetrahydride; In tetrahydrofuran; at 23 ℃; for 3h;

With water; sodium sulfate; In tetrahydrofuran; for 0.5h;

Reference yield:

→ 4-aminomethylquinuclidine (67496-78-0)

Guidance literature:

Chinuclidin-4-carbamid, LiAlH4 (in THF);

DOI:10.1002/hlca.19780610510

Reference yield: 100.0%

methyl 3-formyl-1H-indazole-4-carboxylate (433728-79-1) + 4-aminomethylquinuclidine (67496-78-0) → methyl 3-((quinuclidin-4-ylmethylamino)methyl)-1H-indazole-4-carboxylate (1262420-77-8)

Guidance literature:

methyl 3-formyl-1H-indazole-4-carboxylate; 4-aminomethylquinuclidine; With acetic acid; In 1,4-dioxane; at 60 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In 1,4-dioxane; at 20 ℃; for 4h;

upstream raw materials:

4-cyanoquinuclidine

Downstream raw materials:

N-(1-azabicyclo[2.2.2]octan-4-ylmethyl)-2'-oxo-spiro[cyclopropane-1,3'-[3'H]indole]-1'(2'H)-carboxamide

3-(quinuclidin-4-yl)methyl-4-phenyl-3,4-dihydro-2(1H)-quinazolinone

N-(quinuclidin-4-ylmethyl)-1H-indole-3-carboxamide

3-(7-{6-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]pyridin-3-yl}-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl)phenol

Refernces

• 1、 -. "CEPHEM COMPOUND HAVING PSEUDO-CATECHOL GROUP". Paragraph 0199; 0200. . Retrieved 2013/04/10.
• 2、 -. "4-SUBSTITUTED QUINUCLIDINE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF". Page/Page column 20. . Retrieved 2009/04/24.