26458-78-6

Basic information

• Product Name: 4-CYANOQUINUCLIDINE
• Synonyms: 4-CYANOQUINUCLIDINE;BUTTPARK 31\04-90;quinuclidine-4-carbonitrile;1-Azabicyclo[2.2.2]octane-4-carbonitrile;4-Quinuclidinecarbonitrile;1-Azabicyclo[2.2.2]octane-4-carbonitrile 97%;4-Cyanonquinuclidine, 4-Cyano-1-azabicyclo[2.2.2]octane
• CAS NO: 26458-78-6
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19
• Mol File: 26458-78-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 129-130°C
• Boiling Point: 239℃
• Flash Point: 97℃
• Appearance: /
• Density: 1.09
• Vapor Pressure: 0.0417mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly)
• PKA: 8.02±0.12(Predicted)
• CAS DataBase Reference: 4-CYANOQUINUCLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANOQUINUCLIDINE(26458-78-6)
• EPA Substance Registry System: 4-CYANOQUINUCLIDINE(26458-78-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 26458-78-6(Hazardous Substances Data)

Usage

Uses

4-Cyanoquinuclidine is an intermediate used to prepare pleuromutilin (P610500) derivatives as antimicrobials.

InChI:InChI=1/C8H12N2/c9-7-8-1-4-10(5-2-8)6-3-8/h1-6H2

Upstream product

• 112864-70-7 4-cyano-1-methyl-quinuclidinium; chloride 
• 111041-03-3 1-(2-chloroethyl)piperidine-4-carbonitrile hydrochloride 
• 555-77-1 tris-(2-chloro-ethyl)-amine 
• 75-05-8 acetonitrile 
• 39546-32-2 4-carboxamidopiperidine 
• 62124-30-5 N-(2-hydroxyethyl)-4-carbamoylpiperidine 
• 20691-92-3 1-methylpiperidine-4-carbonitrile 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1690-75-1 1-methyl-piperidine-4-carboxylic acid methyl ester 
• 1453-82-3 isonicotinamide 
• 62718-28-9 1-methylpiperidine-4-carboxamide 
• 7630-02-6 4-(methoxycarbonyl)-1-methylpyridinium iodide 
• 14989-30-1 hypochloric acid 
• 62124-31-6 C₈H₁₅ClN₂O 

Downstream Products

• 26608-58-2 4-hydroxymethylquinuclidine 
• 905848-84-2 (4-aminophenyl)(1-aza-bicyclo[2,2,2]oct-4-yl)-methanone 
• 1609072-34-5 C₃₂H₃₄ClN₃O₅ 
• 1609072-36-7 C₃₂H₃₄ClN₃O₆ 
• 1609072-37-8 C₃₂H₃₄ClN₃O₆ 
• 1609072-55-0 C₃₂H₃₅N₃O₆ 
• 1609072-58-3 C₃₂H₃₅N₃O₅ 
• 1609072-64-1 C₃₂H₃₄ClN₃O₅ 
• 52547-86-1 4-ethynylquinuclidine 
• 40117-63-3 1-azabicyclo[2.2.2]octane-4-carboxylic acid hydrochloride 
• 1338729-21-7 C₂₀H₂₄N₂O₂ 
• 1338729-18-2 C₂₂H₂₇N₃O₄ 
• 1338730-21-4 C₃₅H₃₇N₃O₅ 
• 55022-91-8 quinuclidine-4-carbaldehyde 

Relevant articles and documents

NEW METHOD FOR PREPARATION OF 1-AZABICYCLOOCTANE-4-CARBONITRILE AND 1-AZABICYCLONONANE-5-CARBONITRILE

The title compounds were prepared from pyridine-4-carboxamide.Its alkylation with 2-chloroethanol or 3-chloropropanol, followed by hydrogenation gave 1-substituted piperidine-4-carboxamides IIIa and IIIb, respectively, which on treatment with thionyl chloride were converted into the respective 1-substituted halogenoalkylpiperidine-4-carbonitriles IVa and IVb.On cyclization, compounds IVa and IVb afforded 1-azabicyclooctane-4-carbonitrile and 1-azabicyclononane-5-carbonitrile, respectively.

Pleuromutilin derivatives as antimicrobials

The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.

4-cyanopiperidine derivatives, preparation and use thereof

-