NSC 632839 hydrochloride

Base Information

Chemical Name:NSC 632839 hydrochloride
CAS No.:157654-67-6
Molecular Formula:C21H21NO.ClH
Molecular Weight:339.864
Hs Code.:
European Community (EC) Number:803-109-9
NSC Number:632839
DSSTox Substance ID:DTXSID10417701
ChEMBL ID:CHEMBL1990474
Mol file:157654-67-6.mol

Synonyms:NSC 632839;NSC-632839;NSC632839

Suppliers and Price of NSC 632839 hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NSC 632839
10mg
$ 85.00

TRC
NSC 632839
5mg
$ 55.00

TRC
NSC 632839
50mg
$ 325.00

Tocris
NSC632839hydrochloride ≥99%(HPLC)
50
$ 524.00

Tocris
NSC632839hydrochloride ≥99%(HPLC)
10
$ 129.00

Sigma-Aldrich
NSC 632839 ≥98% (HPLC)
5mg
$ 92.10

Sigma-Aldrich
NSC 632839 ≥98% (HPLC)
25mg
$ 370.00

Medical Isotopes, Inc.
NSC 632839
10 mg
$ 625.00

DC Chemicals
NSC 632839 >98%
1 g
$ 1100.00

Crysdot
NSC632839hydrochloride 98+%
100mg
$ 262.00

Total 15 raw suppliers

Chemical Property of NSC 632839 hydrochloride

Chemical Property:

Vapor Pressure:5.05E-11mmHg at 25°C
Boiling Point:522.7°C at 760 mmHg
Flash Point:184°C
PSA：29.10000
LogP:5.07350
Storage Temp.:Store at +4°C
Solubility.:DMSO: ≥2mg/mL (warmed)
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:339.1389920
Heavy Atom Count:24
Complexity:432

Purity/Quality:

99%, ^*data from raw suppliers

NSC 632839 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,N
Hazard Codes:Xi,N
Statements: 36-51/53
Safety Statements: 26-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C=C2CNCC(=CC3=CC=C(C=C3)C)C2=O.Cl
Isomeric SMILES:CC1=CC=C(C=C1)/C=C\2/C(=O)/C(=C/C3=CC=C(C=C3)C)/CNC2.Cl
Description NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2?Cell permeable.
Uses Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene).

Technology Process of NSC 632839 hydrochloride

There total 1 articles about NSC 632839 hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%