7-chloro-8-fluoro-2-phenylquinoline

Base Information

• Chemical Name: 7-chloro-8-fluoro-2-phenylquinoline
• CAS No.: 867164-92-9
• Molecular Formula: C15H9ClFN
• Molecular Weight: 257.6900632
• Mol file: 867164-92-9.mol

Synonyms:CIS-4-TRIFLUROMETHYL CYCLOHEXANOL;7-chloro-8-fluoro-2-phenylquinoline;7-Chloro-8-fluoro-2-phenyl-1,4-dihydroquinoline-4-one

Chemical Property of 7-chloro-8-fluoro-2-phenylquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 4.69430
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

7-Chloro-8-fluoro-2-phenylquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-chloro-8-fluoro-2-phenylquinoline

There total 2 articles about 7-chloro-8-fluoro-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-7-chloro-8-fluoro-2-phenyl-quinoline (867164-98-5) → 7-chloro-8-fluoro-2-phenylquinoline (867164-92-9)

Guidance literature:

4-bromo-7-chloro-8-fluoro-2-phenyl-quinoline; With n-butyllithium; In tetrahydrofuran; hexane; at -100 - -90 ℃; for 0.1h;

With acetic acid; for 0.333333h; Product distribution / selectivity;

Reference yield:

(E)-3-phenylpropenal (14371-10-9) + 3-chloro-2-fluoroaniline (2106-04-9) → 7-chloro-8-fluoro-2-phenylquinoline (867164-92-9)

Guidance literature:

With hydrogenchloride; In water; toluene; for 40h; Product distribution / selectivity; Heating / reflux;

Reference yield:

7-chloro-8-fluoro-2-phenylquinoline (867164-92-9) + bis(pinacol)diborane (73183-34-3) → 8-fluoro-2-phenyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-quinoline (867164-90-7)

Guidance literature:

With potassium acetate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; palladium diacetate; In tetrahydrofuran; Heating / reflux;

upstream raw materials:

(E)-3-phenylpropenal

3-chloro-2-fluoroaniline

4-bromo-7-chloro-8-fluoro-2-phenyl-quinoline

Downstream raw materials:

8-fluoro-2-phenyl-7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-quinoline

Refernces