(+)-(2S,5S)-2,5-DiMethylpyrrolidine Hydrochloride

Base Information

• Chemical Name: (+)-(2S,5S)-2,5-DiMethylpyrrolidine Hydrochloride
• CAS No.: 138133-34-3
• Molecular Formula: C6H14ClN
• Molecular Weight: 135.637
• Mol file: 138133-34-3.mol

Synonyms:(2S,5S)-2,5-Dimethylpyrrolidine Hydrochloride;

Chemical Property of (+)-(2S,5S)-2,5-DiMethylpyrrolidine Hydrochloride

Chemical Property:

• Melting Point: 187 - 188 °C (diethyl ether)
• PSA: 12.03000
• LogP: 2.27760
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

(2S,5S)-2,5-DimethylpyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2S,5S)-2,5-Dimethylpyrrolidine Hydrochloride is a reagent used for asymmetric synthesis.

Technology Process of (+)-(2S,5S)-2,5-DiMethylpyrrolidine Hydrochloride

There total 9 articles about (+)-(2S,5S)-2,5-DiMethylpyrrolidine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-aminohex-5-ene (7380-76-9,73604-43-0) → trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

2-aminohex-5-ene; With 1,3-bis(2-iPrC₆H₄)-2-bis(TMS)N-2,1,3-scandiadiazolidine; In benzene; at 60 ℃; for 3h;

With hydrogenchloride; In diethyl ether; benzene; at -15 ℃;

DOI:10.1021/ol051574h

Reference yield: 90.0%

(2S,5S)-2,5-dimethylpyrrolidine-1-carboxylic acid benzyl ester (136522-02-6) → trans-(2S,5S)-2,5-dimethylpyrrolidine hydrochloride (138133-34-3)

Guidance literature:

With hydrogenchloride; chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)96049-0

Reference yield: 80.0%

trans-N-(Carbobenzyloxy)-2,5-dimethylpyrrolidine (78329-37-0) → trans-2,5-Dimethylpyrrolidine Hydrochloride (4209-65-8,4832-49-9,63639-02-1,70144-18-2,114143-75-8,138133-34-3)

Guidance literature:

With hydrogenchloride; In acetic acid;

DOI:10.1021/jo00332a036

upstream raw materials:

trans-N-(Carbobenzyloxy)-2,5-dimethylpyrrolidine

2-aminohex-5-ene

hex-5-en-2-one oxime

(E)-hex-5-en-2-one oxime

Downstream raw materials:

2,5-dimethyl-1-(phenylethynyl)-pyrrolidine

(2S-trans)-2,5-Dimethyl-1-<1-oxo-5-(phenylmethoxy)-pentyl>pyrrolidine

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