5-BroMo-6-hydroxypicolinic acid

Base Information

• Chemical Name: 5-BroMo-6-hydroxypicolinic acid
• CAS No.: 1214385-51-9
• Molecular Formula: C6H4BrNO3
• Molecular Weight: 218.00486
• Hs Code.: 2933399090
• Mol file: 1214385-51-9.mol

Synonyms:5-BroMo-6-hydroxypicolinic acid;5-bromo-6-hydroxypyridine-2-carboxylic acid;5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylic acid

Chemical Property of 5-BroMo-6-hydroxypicolinic acid

Chemical Property:

• PSA: 70.42000
• LogP: 1.24790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-6-hydroxypicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-6-hydroxypicolinic acid

There total 1 articles about 5-BroMo-6-hydroxypicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-oxo-1,2-dihydropyridine-6-carboxylic acid (19621-92-2) → 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylic acid (1214385-51-9)

Guidance literature:

With bromine; acetic acid; at 80 ℃; for 16h;

Reference yield: 75.0%

5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylic acid (1214385-51-9) + N-Benzylethanolamine (104-63-2) → 2-benzyl-7-bromo-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione (1420476-83-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; Temperature; Reagent/catalyst; Reflux;

DOI:10.1021/ol303463e

Reference yield: 69.0%

2-(phenethylamino)ethanol (2842-37-7) + 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylic acid (1214385-51-9) → 7-bromo-2-phenethyl-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione (1420476-84-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; Reflux;

DOI:10.1021/ol303463e

upstream raw materials:

2-oxo-1,2-dihydropyridine-6-carboxylic acid

Downstream raw materials:

2-benzyl-7-bromo-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione

C₁₅H₁₅BrN₂O₃

7-bromo-2-phenethyl-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione

2-benzyl-7-bromo-3-methyl-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione

Refernces