2,5-Di(Methoxy-d3)-4-Methylbenzaldehyde

Base Information

• Chemical Name: 2,5-Di(Methoxy-d3)-4-Methylbenzaldehyde
• CAS No.: 58262-07-0
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 186.156
• Mol file: 58262-07-0.mol

Synonyms:2,5-Di(Methoxy-d3)-4-Methylbenzaldehyde;2,5-DiMethoxy-d6-4-Methyl-benzaldehyde

Chemical Property of 2,5-Di(Methoxy-d3)-4-Methylbenzaldehyde

Chemical Property:

• Melting Point: 74-75 °C
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dimethoxy-d6-4-methyl-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,5-Di(Methoxy-d3)-4-Methylbenzaldehyde is used in the preparation of labelled phenylamine derivative as potential psychotomimetics.

Technology Process of 2,5-Di(Methoxy-d3)-4-Methylbenzaldehyde

There total 3 articles about 2,5-Di(Methoxy-d3)-4-Methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Dichloromethyl methyl ether (4885-02-3) + 1,4-[2H6]dimethoxy-2-methylbenzene (58262-06-9) → 2,5-[2H6]dimethoxy-4-methylbenzaldehyde (58262-07-0)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1002/jlcr.1378

Reference yield:

2-methylbenzene-1,4-diol (95-71-6,96937-50-7) → 2,5-[2H6]dimethoxy-4-methylbenzaldehyde (58262-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / KOH; Bu₄NBr / 96 h / 55 °C

2: 87 percent / TiCl₄ / CH₂Cl₂ / 0.25 h / 20 °C

With potassium hydroxide; tetrabutylammomium bromide; titanium tetrachloride; In dichloromethane;

DOI:10.1002/jlcr.1378

Reference yield:

→ 2,5-[2H6]dimethoxy-4-methylbenzaldehyde (58262-07-0)

Guidance literature:

Toluol 13-d6, Methylformamid, POCl3, Formylierung;

DOI:10.1021/ac60365a058

upstream raw materials:

Dichloromethyl methyl ether

1,4-[2H₆]dimethoxy-2-methylbenzene

2-methylbenzene-1,4-diol

Downstream raw materials:

(+/-)-2-(2,5-[2H₆]dimethoxy-4-methylphenyl)-1-methylethylamine