METHYL 6-AMINO-5-METHOXYNICOTINATE

Base Information

• Chemical Name: METHYL 6-AMINO-5-METHOXYNICOTINATE
• CAS No.: 365413-06-5
• Molecular Formula: C8H10N2O3
• Molecular Weight: 182.18
• Mol file: 365413-06-5.mol

Synonyms:METHYL 6-AMINO-5-METHOXYNICOTINATE

Chemical Property of METHYL 6-AMINO-5-METHOXYNICOTINATE

Chemical Property:

• PSA: 74.44000
• LogP: 1.04020

Purity/Quality:

98%min ^*data from raw suppliers

METHYL 6-AMINO-5-METHOXYNICOTINATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 6-AMINO-5-METHOXYNICOTINATE

There total 5 articles about METHYL 6-AMINO-5-METHOXYNICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl 5-methoxy-6-nitropyridine-3-carboxylate → methyl 6-amino-5-methoxypyridine-3-carboxylate (365413-06-5)

Guidance literature:

With iron; acetic acid; In methanol; for 3h;

Reference yield:

5-hydroxynicotinic acid (27828-71-3) → methyl 6-amino-5-methoxypyridine-3-carboxylate (365413-06-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid; nitric acid / 16 h / 0 - 20 °C / Sealed tube

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 5 - 10 °C

2.2: 3 h / 20 °C

3.1: acetic acid; iron / methanol / 3 h

With sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

5-hydroxy-6-nitropyridine-3-carboxylic acid (59288-43-6) → methyl 6-amino-5-methoxypyridine-3-carboxylate (365413-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 5 - 10 °C

1.2: 3 h / 20 °C

2.1: acetic acid; iron / methanol / 3 h

With iron; potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

5-hydroxynicotinic acid

5-hydroxy-6-nitropyridine-3-carboxylic acid

methyl 5-hydroxy-6-nitronicotinate

methyl 5-hydroxy-3-pyridinecarboxylate

Refernces

• 1、 -. "Substituted dihydropyrido[3,4-b]pyrazinones as dual inhibitors of bet proteins and polo-like kinases". Paragraph 0243. . Retrieved 2016/10/10.