3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester

Base Information

• Chemical Name: 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester
• CAS No.: 641569-95-1
• Molecular Formula: C₁₁H₁₅N₃O₂
• Molecular Weight: 221.259
• Mol file: 641569-95-1.mol

Synonyms:3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester

Chemical Property of 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester

There total 2 articles about 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

CYANAMID (420-04-2) + 3-amino-4-methylbenzoic acid ethyl ester (41191-92-8) → C11H15N3O2 (641569-95-1)

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.2533/chimia.2019.561

Reference yield:

3-amino-p-toluic acid (2458-12-0) → C11H15N3O2 (641569-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 12 h / Reflux; Inert atmosphere

2: hydrogenchloride / ethanol; water / 15 h / Reflux

With hydrogenchloride; sulfuric acid; In ethanol; water;

DOI:10.1111/cbdd.12272

Reference yield:

C11H15N3O2 (641569-95-1) → 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid (641569-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium nitrate / 0.5 h / 0 °C

2: sodium hydroxide / butan-1-ol / 72 h / Reflux; Inert atmosphere

3: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C

With ammonium nitrate; sodium hydroxide; In ethanol; water; butan-1-ol;

DOI:10.1111/cbdd.12272

upstream raw materials:

3-amino-p-toluic acid

CYANAMID

3-amino-4-methylbenzoic acid ethyl ester

Downstream raw materials:

N-(3-bromo-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide