(Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide

Base Information

• Chemical Name: (Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide
• CAS No.: 265977-72-8
• Molecular Formula: C₂₁H₂₁ClN₂O₂
• Molecular Weight: 368.863
• Hs Code.: 2933399090
• Mol file: 265977-72-8.mol

Synonyms:(Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide

Chemical Property of (Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide

Chemical Property:

• Boiling Point: 597.5±50.0 °C(Predicted)
• PKA: 9.63±0.46(Predicted)
• PSA: 52.90000
• Density: 1.242±0.06 g/cm3(Predicted)
• LogP: 4.54920
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(Z)-N-(1-Chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide

There total 7 articles about (Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

N-(1-oxo-3-phenyl-1-(piperidin-1-yl)-prop-2-en-2-yl)benzamide (356791-01-0,38879-55-9) → (Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide (265977-72-8,211363-59-6,300669-68-5)

Guidance literature:

With thionyl chloride; at 20 ℃;

DOI:10.1016/j.ejmech.2015.05.032

Reference yield:

4-benzylidene-2-phenyloxazole-5(4H)-one (842-74-0,5839-91-8) → (Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide (265977-72-8,211363-59-6,300669-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 0 °C

2: thionyl chloride / 20 °C

With thionyl chloride; In dichloromethane;

DOI:10.1016/j.ejmech.2015.05.032

Reference yield:

benzaldehyde (100-52-7) → (Z)-N-(1-chloro-3-oxo-1-phenyl-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide (265977-72-8,211363-59-6,300669-68-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium acetate; acetic anhydride / 0.5 h / Reflux

2: dichloromethane / 1 h / 0 °C

3: thionyl chloride / 20 °C

With thionyl chloride; potassium acetate; acetic anhydride; In dichloromethane;

DOI:10.1016/j.ejmech.2015.05.032

upstream raw materials:

piperidine

4-benzylidene-2-phenyloxazole-5(4H)-one

benzaldehyde

N-(1-oxo-3-phenyl-1-(piperidin-1-yl)-prop-2-en-2-yl)benzamide

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