2,3,4,5,6-PENTAMETHYLPHENYLBORONIC ACID

Base Information

• Chemical Name: 2,3,4,5,6-PENTAMETHYLPHENYLBORONIC ACID
• CAS No.: 1028205-76-6
• Molecular Formula: C11H17BO2
• Molecular Weight: 192.06
• Mol file: 1028205-76-6.mol

Synonyms:2,3,4,5,6-PENTAMETHYLPHENYLBORONIC ACID;AKOS BRN-0629

Chemical Property of 2,3,4,5,6-PENTAMETHYLPHENYLBORONIC ACID

Chemical Property:

• Melting Point: 185 °C(Solv: water (7732-18-5))
• Boiling Point: 368.8±52.0 °C(Predicted)
• PKA: 9.12±0.58(Predicted)
• PSA: 40.46000
• Density: 1.02±0.1 g/cm3(Predicted)
• LogP: 0.90840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,3,4,5,6-PentamethylphenylboronicAcid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5,6-PENTAMETHYLPHENYLBORONIC ACID

There total 2 articles about 2,3,4,5,6-PENTAMETHYLPHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Trimethyl borate (121-43-7,63156-11-6) + 2,3,4,5,6-pentamethylbromobenzene (5153-40-2) → (2,3,4,5,6-pentamethylphenyl)boronic acid (1028205-76-6)

Guidance literature:

With LiC(CH₃)3; HCl; In tetrahydrofuran; (under Ar, Schlenk); soln. of ligand in THF cooled to -90°C, LiC(CH3)3 added, stirred for 45 min at -65°C, treated with B(OCH3)3, warmed to room temp., stirred overnight, H2O added, acidified by HCl pH 3-5; extd. with Et2O, organic layer washed with brine, H2O, dried over MgSO4,solvent removed, residue refluxed in H2O for 2 h, filtered, filtrate co oled to 0°C for 10 min, ppt. filtered, washed with pentane, H2O, recrystd. from H2O; elem. anal.;

DOI:10.1039/b719282g

Reference yield:

C13H21BO2 → (2,3,4,5,6-pentamethylphenyl)boronic acid (1028205-76-6)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; pentane;

DOI:10.1039/b719282g

Reference yield: 55.0%

(2,3,4,5,6-pentamethylphenyl)boronic acid (1028205-76-6) + C42H28Br2 → C64H58

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate tribasic heptahydrate; palladium diacetate; In toluene; at 110 ℃;

DOI:10.1039/c8sc03236j

upstream raw materials:

Trimethyl borate

2,3,4,5,6-pentamethylbromobenzene

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