3-Oxo-5α-24-cholanoic acid methyl ester

Base Information

• Chemical Name: 3-Oxo-5α-24-cholanoic acid methyl ester
• CAS No.: 15074-03-0
• Molecular Weight: 388.58
• Mol file: 15074-03-0.mol

Synonyms:

Chemical Property of 3-Oxo-5α-24-cholanoic acid methyl ester

Chemical Property:

• Melting Point: 117-118 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 471.9±18.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.034±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Oxo-5α-24-cholanoic acid methyl ester

There total 16 articles about 3-Oxo-5α-24-cholanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 3β-hydroxy-5α-cholan-24-oate (1249-75-8,5405-42-5,15074-01-8,15074-02-9,20231-51-0,63814-53-9,106757-10-2,125412-30-8) → (R)-methyl 4-((5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (15074-03-0)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 15 ℃; for 16h;

Reference yield: 55.0%

choladiene-1,4 one-3 oate-24 de methyle (73409-98-0) → (R)-methyl 4-((5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (15074-03-0) + methyl 3-oxo-5β-cholan-24-oate (1173-32-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; under 735.5 Torr; Ambient temperature;

DOI:10.1016/0039-128X(89)90022-6

Reference yield:

→ 3-Keto-cholansaeure-methylester (1173-32-6,15074-03-0,70982-52-4)

Guidance literature:

entspr. Δ¹-Verb., Hydrierung ueber Pd/C in A.-Lsg.;

DOI:10.1021/jo01062a047

upstream raw materials:

diazomethane

(+)-3-oxo-5α-cholan-24-oic acid

methyl 3β-hydroxy-5α-cholan-24-oate

choladiene-1,4 one-3 oate-24 de methyle