choladiene-1,4 one-3 oate-24 de methyle

Base Information

• Chemical Name: choladiene-1,4 one-3 oate-24 de methyle
• CAS No.: 73409-98-0
• Molecular Formula: C₂₅H₃₆O₃
• Molecular Weight: 384.559
• Mol file: 73409-98-0.mol

Synonyms:choladiene-1,4 one-3 oate-24 de methyle

Chemical Property of choladiene-1,4 one-3 oate-24 de methyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of choladiene-1,4 one-3 oate-24 de methyle

There total 2 articles about choladiene-1,4 one-3 oate-24 de methyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

methyl 3-oxo-5β-cholan-24-oate (1173-32-6) → choladiene-1,4 one-3 oate-24 de methyle (73409-98-0) + methyl 3-oxo-4-cholenolate (1452-33-1) + 5β cholene-1, one-3, oate-24 de methyle (91667-86-6)

Guidance literature:

With diphenyl diselenide; 3-iodylbenzoic acid; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

C25H39BrO3 (1414953-61-9) + 2,4-didromo-3-oxo lithicholic acid methyl ester (99598-20-6) + (R)-4-((5S,8S,9S,10R,13R,14S,17R)-4-Bromo-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester (112018-64-1) → choladiene-1,4 one-3 oate-24 de methyle (73409-98-0) + methyl 3-oxo-4-cholenolate (1452-33-1) + 5β cholene-1, one-3, oate-24 de methyle (91667-86-6)

Guidance literature:

With Li₂CO₃; lithium bromide; In N,N-dimethyl-formamide; Overall yield = 48 %;

DOI:10.1016/j.bmcl.2012.09.040

Reference yield: 55.0%

choladiene-1,4 one-3 oate-24 de methyle (73409-98-0) → (R)-methyl 4-((5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (15074-03-0) + methyl 3-oxo-5β-cholan-24-oate (1173-32-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; under 735.5 Torr; Ambient temperature;

DOI:10.1016/0039-128X(89)90022-6

upstream raw materials:

methyl 3-oxo-5β-cholan-24-oate

C₂₅H₃₉BrO₃

2,4-didromo-3-oxo lithicholic acid methyl ester

(R)-4-((5S,8S,9S,10R,13R,14S,17R)-4-Bromo-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

Downstream raw materials:

(R)-methyl 4-((5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

methyl 3-oxo-5β-cholan-24-oate

methyl 3-oxo-4-cholenolate

methyl 3β-hydroxy-5α-cholan-24-oate