3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

Base Information

Chemical Name:3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester
CAS No.:912265-93-1
Molecular Formula:C12H16N2O5
Molecular Weight:268.269
Hs Code.:
Mol file:912265-93-1.mol

Synonyms:3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

Suppliers and Price of 3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylicacid 95+%
1g
$ 1058.00

AK Scientific
5-[(Tert-Butoxy)Carbonyl]-4H,5H,6H,7H-[1,2]Oxazolo[4,5-C]Pyridine-3-CarboxylicAcid
5g
$ 3365.60

Total 8 raw suppliers

Chemical Property of 3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

Chemical Property:

Boiling Point:452.3±45.0 °C(Predicted)
PKA:3.27±0.20(Predicted)
PSA：92.87000
Density:1.321±0.06 g/cm3(Predicted)
LogP:1.60390

Purity/Quality:

97% ^*data from raw suppliers

5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester

There total 11 articles about 3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 912265-92-0
6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid-3-ethyl ester-5-tert-butyl ester

: 912265-93-1
5-[(tert-butoxy)carbonyl]-4H,5H,6H,7H-[1,2]oxazolo[4,5-c]pyridine-3-carboxylic acid

Guidance literature:: With lithium hydroxide; In ethanol; at 20 ℃; for 12h;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 912265-93-1
5-[(tert-butoxy)carbonyl]-4H,5H,6H,7H-[1,2]oxazolo[4,5-c]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

2.1: triethylamine / dichloromethane / 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0 °C / Reflux

3.2: 0 °C

4.1: dichloromethane / 0 - 20 °C

5.1: lithium hydroxide / ethanol / 0 - 20 °C

With triethylamine; trifluoroacetic acid; lithium hydroxide; toluene-4-sulfonic acid; In ethanol; dichloromethane; toluene;

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 912265-93-1
5-[(tert-butoxy)carbonyl]-4H,5H,6H,7H-[1,2]oxazolo[4,5-c]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 12 h / Heating / reflux

2.1: dichloromethane / 20 °C

2.2: 12 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 8 h / Heating / reflux

4.1: hydrogenchloride / ethanol; water / 2 h / 20 °C / Heating / reflux

5.1: triethylamine / 1,4-dioxane; water / 12 h / 0 - 20 °C

6.1: lithium hydroxide / ethanol / 12 h / 20 °C

With hydrogenchloride; lithium hydroxide; triethylamine; trifluoroacetic acid; toluene-4-sulfonic acid; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;