tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate

Base Information

Chemical Name:tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate
CAS No.:1172623-98-1
Molecular Formula:C16H19F2NO3
Molecular Weight:311.329
Hs Code.:
Mol file:1172623-98-1.mol

Synonyms:tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate;N-[(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]-Carbamic acid 1,1-dimethylethyl ester;Carbamic acid, N-[(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]-, 1,1-dimethylethyl ester

Suppliers and Price of tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
tert-Butyl((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate 95%
1g
$ 393.00

Ambeed
tert-Butyl((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate 95+%
5g
$ 309.00

Ambeed
tert-Butyl((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate 95+%
1g
$ 77.00

Ambeed
tert-Butyl((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate 95+%
250mg
$ 36.00

Alichem
tert-Butyl((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate
1g
$ 424.20

AK Scientific
tert-Butyl((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate
1g
$ 416.00

Total 52 raw suppliers

Chemical Property of tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate

Chemical Property:

Boiling Point:395.8±42.0 °C(Predicted)
PKA:11.18±0.40(Predicted)
PSA：47.56000
Density:1.21±0.1 g/cm3(Predicted)
LogP:4.22410
Storage Temp.:Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl((2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl)carbamate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate

There total 15 articles about tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.1%

: tert-butyl [(1R,2S)-1-(2,5-difluorophenyl)-1-hydroxypent-4-yn-2-yl]carbamate

: 1172623-98-1
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbamate

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); tert-butylammonium hexafluorophosphate(V); sodium hydrogencarbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

Reference yield: 87.0%

: C₁₆H₁₉F₂NO₃

: 1172623-98-1
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbamate

: tert-butyl [(2R,3R)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbamate

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); tert-butylammonium hexafluorophosphate(V); sodium hydrogencarbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 85 ℃; for 26h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;
DOI:10.1021/ol502661g

Reference yield:

: tert-butyl [(1S,2S)-1-(2,5-difluorophenyl)-1-hydroxypent-4-yn-2-yl]carbamate

: 1172623-98-1
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbamate

Guidance literature:: tert-butyl [(1S,2S)-1-(2,5-difluorophenyl)-1-hydroxypent-4-yn-2-yl]carbamate; With 1-hydroxy-pyrrolidine-2,5-dione; tert-butylammonium hexafluorophosphate(V); sodium hydrogencarbonate; In N,N-dimethyl-formamide; Inert atmosphere; Large scale;

With chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); triphenylphosphine; In N,N-dimethyl-formamide; at 75 - 85 ℃; Inert atmosphere; Large scale;