3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE

Base Information

• Chemical Name: 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE
• CAS No.: 36822-08-9
• Molecular Formula: C₁₀H₆N₂OS
• Molecular Weight: 202.236
• Mol file: 36822-08-9.mol

Synonyms:3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE;AKOS 92531;AKOS B030310

Chemical Property of 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE

Chemical Property:

• Melting Point: >230°C
• PSA: 74.25000
• LogP: 2.55010
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE

There total 13 articles about 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3-aminobenzothiophene-2-carboxylate (34761-09-6) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4-Hydroxy-benzothieno<3,2-d>pyrimidin (36822-08-9)

Guidance literature:

With formamidine acetic acid; at 150 ℃; for 6h;

Reference yield: 94.1%

ethyl 3-aminobenzothiophene-2-carboxylate (34761-09-6) + formamidine acetic acid (3473-63-0) → <1>benzothieno<3,2-d>pyrimidin-4(3H)-one (36822-08-9)

Guidance literature:

In 2-methoxy-ethanol; at 150 ℃; Inert atmosphere;

Reference yield: 79.0%

ethyl 3-aminobenzothiophene-2-carboxylate (34761-09-6) + formamide (77287-34-4,77287-35-5,60100-09-6) → <1>benzothieno<3,2-d>pyrimidin-4(3H)-one (36822-08-9)

Guidance literature:

at 140 - 180 ℃; for 22h;

DOI:10.1002/jhet.5570340412

upstream raw materials:

3-Amino-benzo[b]thiophene-2-carboxylic acid methyl ester

2-fluorobenzonitrile

ethyl 3-aminobenzothiophene-2-carboxylate

formamide

Downstream raw materials:

4-chloro-3,4-dihydrobenzo[4,5]thiophene[3,2-d]pyrimidine

3H-benzyl-3 benzothieno<3,2-d>pyrimidone-4

N-(2-methylphenyl)benzo[4,5]thieno[3,2-d]pyrimidin-4-amine

N-(2-methylbenzyl)benzo[4,5]thieno[3,2-d]pyrimidin-4-amine

Refernces

• 1、 -. "Bicarbazole containing compounds for OLED". Paragraph 0074. . Retrieved 2015/02/02.
• 2、 -. "PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE". . . Retrieved 2012/10/18.