Spiro[cyclopentane-1,2(3H)-indolizin]-7(1H)-one, tetrahydro- (9CI)

Base Information

Chemical Name:Spiro[cyclopentane-1,2(3H)-indolizin]-7(1H)-one, tetrahydro- (9CI)
CAS No.:443984-31-4
Molecular Formula:C12H19NO
Molecular Weight:193.28536
Hs Code.:
Mol file:443984-31-4.mol

Synonyms:Spiro[cyclopentane-1,2(3H)-indolizin]-7(1H)-one, tetrahydro- (9CI)

Suppliers and Price of Spiro[cyclopentane-1,2(3H)-indolizin]-7(1H)-one, tetrahydro- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Spiro[cyclopentane-1,2(3H)-indolizin]-7(1H)-one, tetrahydro- (9CI)

Chemical Property:

PSA：20.31000
LogP:1.92190

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of Spiro[cyclopentane-1,2(3H)-indolizin]-7(1H)-one, tetrahydro- (9CI)

There total 3 articles about Spiro[cyclopentane-1,2(3H)-indolizin]-7(1H)-one, tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 443984-30-3
1-aminomethyl-1-formylmethylcyclopentane diethyl acetal

: 78-94-4,25038-87-3
methyl vinyl ketone

: 443984-31-4
(+/-)-2-spirocyclopentane-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one

Guidance literature:: 1-aminomethyl-1-formylmethylcyclopentane diethyl acetal; methyl vinyl ketone; In diethyl ether; at 0 - 20 ℃; for 24h;

With hydrogenchloride; In water; at 100 ℃; for 3h;

With sodium hydrogencarbonate; In water; at 20 ℃;

Reference yield:

: 4254-02-8
cyclopentanecarbonitrile

: 443984-31-4
(+/-)-2-spirocyclopentane-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: -78 °C / Cooling with acetone-dry ice

2.1: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran / 1.17 h / 0 °C

2.2: 2 h / 20 °C

2.3: 0 °C

3.1: diethyl ether / 24 h / 0 - 20 °C

3.2: 3 h / 100 °C

3.3: 20 °C

With lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane;

Reference yield:

: 443984-29-0,471864-45-6
1-cyano-1-formylmethylcyclopentane diethyl acetal

: 443984-31-4
(+/-)-2-spirocyclopentane-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran / 1.17 h / 0 °C

1.2: 2 h / 20 °C

1.3: 0 °C

2.1: diethyl ether / 24 h / 0 - 20 °C

2.2: 3 h / 100 °C

2.3: 20 °C

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; diethyl ether;