(2S,4S)-1-TERT-BUTYL 2-METHYL 4-BENZYL-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE

Base Information

Chemical Name:(2S,4S)-1-TERT-BUTYL 2-METHYL 4-BENZYL-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE
CAS No.:612820-01-6
Molecular Formula:C18H23NO5
Molecular Weight:333.382
Hs Code.:
Mol file:612820-01-6.mol

Synonyms:(2S,4S)-1-TERT-BUTYL 2-METHYL 4-BENZYL-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE;(2S,4S)-1-tert-butyl 2-Methyl 4-phenoxypyrrolidine-1,2-dicarboxylate;(2S,4R)-5-Oxo-4-(phenylmethyl)-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester;(2S,4R)-1-tert-butyl 2-methyl 4-phenoxypyrrolidine-1,2-dicarboxylate

Suppliers and Price of (2S,4S)-1-TERT-BUTYL 2-METHYL 4-BENZYL-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-1-TERT-BUTYL 2-METHYL 4-BENZYL-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE

Chemical Property:

Melting Point:98-99℃
PSA：72.91000
LogP:2.49220

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4S)-1-TERT-BUTYL 2-METHYL 4-BENZYL-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE

There total 3 articles about (2S,4S)-1-TERT-BUTYL 2-METHYL 4-BENZYL-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 100-39-0
benzyl bromide

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 612820-01-6
(2S,4R)-4-benzyl-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

benzyl bromide; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 612820-01-6
(2S,4R)-4-benzyl-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / Et₃N; DMAP

2.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 53 percent / tetrahydrofuran / 2.5 h

With dmap; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/ejoc.200400916

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 612820-01-6
(2S,4R)-4-benzyl-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / Et₃N; DMAP

2.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 53 percent / tetrahydrofuran / 2.5 h

With dmap; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/ejoc.200400916