(S)-N-Boc-2-(4'-pentenyl)alanine

Base Information

• Chemical Name: (S)-N-Boc-2-(4'-pentenyl)alanine
• CAS No.: 1263048-46-9
• Molecular Formula: C13H23NO4
• Molecular Weight: 257.33
• Mol file: 1263048-46-9.mol

Synonyms:(S)-N-Boc-2-(4'-pentenyl)alanine;(S)-2-((tert-Butoxycarbonyl)amino)-2-methylhept-6-enoic acid

Chemical Property of (S)-N-Boc-2-(4'-pentenyl)alanine

Chemical Property:

• PSA: 75.63000
• LogP: 3.10160

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-((tert-Butoxycarbonyl)amino)-2-methylhept-6-enoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-N-Boc-2-(4'-pentenyl)alanine

There total 11 articles about (S)-N-Boc-2-(4'-pentenyl)alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(3S,5S,6R)-tert-butyl 3-methyl-2-oxo-3-(pent-4-enyl)-5,6-diphenylmorpholine-4-carboxylate (1263048-45-8) → (S)-2-(tert-butoxycarbonyl)amino-2-methylhept-6-enoic acid (1263048-46-9)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; ethanol; at -78 ℃; for 0.25h;

DOI:10.1039/c3cc45231j

Reference yield:

C23H29NO5 → (S)-2-(tert-butoxycarbonyl)amino-2-methylhept-6-enoic acid (1263048-46-9)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / benzene

2: sodium hexamethyldisilazane / tetrahydrofuran

3: potassium hexamethylsilazane / tetrahydrofuran

4: sodium; ammonia; ethanol / tetrahydrofuran

With ethanol; ammonia; sodium hexamethyldisilazane; sodium; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

Reference yield:

(2S,3R)-tert-butyl 6-oxo-2,3-diphenylmorpholine-4-carboxylate (173397-90-5) → (S)-2-(tert-butoxycarbonyl)amino-2-methylhept-6-enoic acid (1263048-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / tetrahydrofuran

2: potassium hexamethylsilazane / tetrahydrofuran

3: sodium; ammonia; ethanol / tetrahydrofuran

With ethanol; ammonia; sodium hexamethyldisilazane; sodium; potassium hexamethylsilazane; In tetrahydrofuran;

upstream raw materials:

tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate

(3S,5S,6R)-4-(tert-butyloxycarbonyl)-5,6-diphenyl-3-methyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

(3S,5S,6R)-tert-butyl 3-methyl-2-oxo-3-(pent-4-enyl)-5,6-diphenylmorpholine-4-carboxylate

n-Pent-4-enyl alcohol

Downstream raw materials:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylhept-6-enoic acid