TERT-BUTYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE

Base Information

Chemical Name:TERT-BUTYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE
CAS No.:173397-90-5
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:
Mol file:173397-90-5.mol

Synonyms:N-TERT-BUTOXYCARBONYL-(2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINE;N-BOC(2R, 3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINE CARBOXYLATE

Suppliers and Price of TERT-BUTYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AstaTech
(2S,3R)-N-BOC-6-OXO-2,3-DIPHENYLMORPHOLINE 95%
25 / G
$ 731.00

AstaTech
(2S,3R)-N-BOC-6-OXO-2,3-DIPHENYLMORPHOLINE 95%
5 / G
$ 244.00

AstaTech
(2S,3R)-N-BOC-6-OXO-2,3-DIPHENYLMORPHOLINE 95%
1 / G
$ 81.00

Total 2 raw suppliers

Chemical Property of TERT-BUTYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE

Chemical Property:

Melting Point:206 °C (dec.)(lit.)
PSA：55.84000
LogP:4.20080

Purity/Quality:

97% ^*data from raw suppliers

(2S,3R)-N-BOC-6-OXO-2,3-DIPHENYLMORPHOLINE 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE

There total 17 articles about TERT-BUTYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 112741-70-5
(1'S,2'R)-ethyl N-(tert-butyloxycarbonyl)-N-(1',2'-diphenyl-2'-hydroxyethyl)glycinate

: 112741-49-8,173397-90-5
tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 120 ℃;

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 100678-82-8
2-((1S,2R)-2-hydroxy-1,2-diphenylethylamino)acetic acid ethyl ester

: 112741-49-8,173397-90-5
tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate

Guidance literature:: di-tert-butyl dicarbonate; 2-((1S,2R)-2-hydroxy-1,2-diphenylethylamino)acetic acid ethyl ester; In toluene; at 110 ℃; for 13h;

With toluene-4-sulfonic acid; In toluene; at 110 ℃; for 1h;
DOI:10.1039/c3cc45231j

Reference yield:

: 23190-16-1
(1R,2S)-2-Amino-1,2-diphenylethanol

: 112741-49-8,173397-90-5
tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 1 h / 20 °C

2: toluene / 10 h / Heating

3: p-TsOH*H₂O / toluene

With toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1055/s-2005-863740