Technology Process of (5-bromo-3-fluoropyridin-2-yl)methanamine
There total 5 articles about (5-bromo-3-fluoropyridin-2-yl)methanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
ethanol;
at 50 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride / water / 30 h / Reflux
2: methanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 - 20 °C
3: phosphorus tribromide / dichloromethane / 4 h / 0 - 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
5: hydrazine hydrate / ethanol / 6 h / 50 °C
With
hydrogenchloride; methanol; sodium tetrahydroborate; hydrazine hydrate; phosphorus tribromide; potassium carbonate;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: methanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 - 20 °C
2: phosphorus tribromide / dichloromethane / 4 h / 0 - 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
4: hydrazine hydrate / ethanol / 6 h / 50 °C
With
methanol; sodium tetrahydroborate; hydrazine hydrate; phosphorus tribromide; potassium carbonate;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
