Sparsentan

Base Information

Chemical Name:Sparsentan
CAS No.:254740-64-2
Molecular Formula:C32H40N4O5S
Molecular Weight:592.75
Hs Code.:
European Community (EC) Number:839-064-7
UNII:9242RO5URM
Nikkaji Number:J2.228.316B
Wikidata:Q27088845
NCI Thesaurus Code:C152412
RXCUI:2630535
Pharos Ligand ID:XJT4977Q6T7L
Metabolomics Workbench ID:153517
ChEMBL ID:CHEMBL539423
Mol file:254740-64-2.mol

Synonyms:(1,1'-biphenyl)-2-sulfonamide, 4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-;4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)-2-biphenylsulfonamide;4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)biphenyl-2-sulfonamide;RE-021;sparsentan

Suppliers and Price of Sparsentan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RE201
10mg
$ 1320.00

TRC
RE201
1mg
$ 165.00

Sigma-Aldrich
Sparsentan ≥98% (HPLC)
25MG
$ 369.00

Sigma-Aldrich
Sparsentan ≥98% (HPLC)
5MG
$ 89.00

Medical Isotopes, Inc.
RE201
10 mg
$ 2200.00

DC Chemicals
Sparsentan(PS433540) >98%
100 mg
$ 700.00

DC Chemicals
Sparsentan(PS433540) >98%
250 mg
$ 1200.00

ChemScene
Sparsentan 99.08%
100mg
$ 1250.00

ChemScene
Sparsentan 99.08%
50mg
$ 750.00

ChemScene
Sparsentan 99.08%
25mg
$ 450.00

Total 34 raw suppliers

Chemical Property of Sparsentan

Chemical Property:

Melting Point:148 °C(Solv: isopropanol (67-63-0); water (7732-18-5))
Boiling Point:744.4±70.0 °C(Predicted)
PKA:7.06±0.50(Predicted)
PSA：122.48000
Density:1.28±0.1 g/cm3(Predicted)
LogP:7.06670
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:592.27194156
Heavy Atom Count:42
Complexity:1060

Purity/Quality:

99%, ^*data from raw suppliers

RE201 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
Recent ClinicalTrials:Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)
Recent EU Clinical Trials:A Phase 2, Open-Label, Single-Arm, Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Sparsentan Treatment in Pediatric Subjects with Selected Proteinuric Glomerular Diseases (EPPIK).
Description Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
Uses RE 201 is used an Endothelin A receptor antagonist used in the treatment of hypertension.

Technology Process of Sparsentan

There total 18 articles about Sparsentan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%