4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide

Base Information

Chemical Name:4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide
CAS No.:1026355-73-6
Molecular Formula:C₃₄H₄₄N₄O₆S
Molecular Weight:636.813
Hs Code.:

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide

Synonyms:4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl-N-](4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide

There total 9 articles about 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[methoxymethyl]-N-(4,5-dimethyl-3-isoxazolyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

: 1-bromo-4-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-2-ethoxymethylbenzene dioxalate

: 1026355-73-6
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl-N-](4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide

Guidance literature:: 1-bromo-4-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-2-ethoxymethylbenzene dioxalate; With sodium hydroxide; In water; pH=8 - 9; Inert atmosphere;

N-[methoxymethyl]-N-(4,5-dimethyl-3-isoxazolyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide; With sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; at 70 ℃;

Reference yield:

: 138402-05-8
2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one

: 1026273-26-6
4'-(bromomethyl)-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide

: 1026355-73-6
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl-N-](4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide

Guidance literature:: 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4'-(bromomethyl)-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/jm049548x

Reference yield:

: 41963-20-6
4-bromo-3-methylbenzonirtile

: 1026355-73-6
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl-N-](4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 17 g / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 4 h / Heating

2.1: 77 percent / dimethylformamide / 16 h / 20 °C

3.1: 80 percent / DIBAL-H / tetrahydrofuran; hexane / 3 h / 20 °C

4.1: 82 percent / Pd(PPh₃)4; aq. Na₂CO₃ / aq. ethanol; toluene / 3 h / 85 °C

5.1: NaBH₄ / methanol / 1 h / 20 °C

6.1: 6.07 g / CBr₄; PPh₃ / dimethylformamide / 3 h / 0 °C

7.1: NaH / dimethylformamide / 0.5 h / 20 °C

7.2: 1.36 g / dimethylformamide / 5 h / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; sodium carbonate; triphenylphosphine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; hexane; N,N-dimethyl-formamide; toluene; 4.1: Suzuki coupling;
DOI:10.1021/jm049548x