5-bromo-2-methoxybenzohydrazide

Base Information

• Chemical Name: 5-bromo-2-methoxybenzohydrazide
• CAS No.: 24123-34-0
• Molecular Formula: C8H9BrN2O2
• Molecular Weight: 245.076
• Hs Code.: 2928000090
• Mol file: 24123-34-0.mol

Synonyms:5-bromo-2-methoxybenzohydrazide

Chemical Property of 5-bromo-2-methoxybenzohydrazide

Chemical Property:

• PSA: 64.35000
• LogP: 2.15240

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-methoxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-methoxybenzohydrazide

There total 3 articles about 5-bromo-2-methoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.7%

methyl 5-bromo-2-methoxybenzoate (7120-41-4) → 5-bromo-2-methoxy benzohydrazide (24123-34-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 100 ℃; for 2h; Microwave irradiation;

Reference yield:

5-bromo-2-methoxybenzoic acid (2476-35-9) → 5-bromo-2-methoxy benzohydrazide (24123-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1.5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: hydrazine hydrate / ethanol / 2 h / 100 °C / Microwave irradiation

With oxalyl dichloride; hydrazine hydrate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

→ 5-bromo-2-methoxy benzohydrazide (24123-34-0)

Guidance literature:

entspr.Ester I, H2NNH2*H2O;

upstream raw materials:

methyl 5-bromo-2-methoxybenzoate

5-bromo-2-methoxybenzoic acid

Downstream raw materials:

N-(2-methoxy-5-bromobenzamido)-N'-phenylthiourea

(E)-N'-(1-(1H-indol-2-yl)ethylidene)-5-bromo-2-methoxybenzohydrazide

(E)-N'-[(1H-indol-2-yl)methylene]-5-bromo-2-methoxybenzohydrazide

Refernces

• 1、 -. "COMPOUND HAVING ZNF143 INHIBITORY ACTIVITY AND USE THEREOF". Paragraph 0269; 0270. . Retrieved 2016/10/27.
• 2、 Kumar, Nag S.,Amandoron, Emily A.,Cherkasov, Artem,Brett Finlay,Gong, Huansheng,Jackson, Linda,Kaur, Sukhbir,Lian, Tian,Moreau, Anne,Labrière, Christophe,Reiner, Neil E.,See, Raymond H.,Strynadka, Natalie C.,Thorson, Lisa,Wong, Edwin W.Y.,Worrall, Liam,Zoraghi, Roya,Young, Robert N.. "Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents". . p. 7069 - 7082. Retrieved 2013/01/15.