methyl 5-bromo-2-methoxybenzoate

Base Information

• Chemical Name: methyl 5-bromo-2-methoxybenzoate
• CAS No.: 7120-41-4
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Hs Code.: 2918990090
• Mol file: 7120-41-4.mol

Synonyms:methyl 2-methoxy-5-bromobenzoate;methyl 5-bromo-o-anisate;5-bromo-2-methoxy-benzoic acid methyl ester;Benzoic acid,5-bromo-2-methoxy-,methyl ester;2-methoxy-5-bromobenzoic acid methyl ester;methyl 5-bromo-2-methoxy-1-benzoate;

Chemical Property of methyl 5-bromo-2-methoxybenzoate

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 39-40 °C
• Boiling Point: 295.186oC at 760 mmHg
• Flash Point: 132.324oC
• PSA: 35.53000
• Density: 1.463g/cm3
• LogP: 2.24430
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl5-bromo-2-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-bromo-2-methoxybenzoate

There total 14 articles about methyl 5-bromo-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methoxybenzoic acid methyl ester (606-45-1) → methyl 5-bromo-2-methoxybenzoate (7120-41-4)

Guidance literature:

With N-Bromosuccinimide; silver hexafluoroantimonate; 1-methylthiotriptycene; In 1,2-dichloro-ethane; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.9b12672

Reference yield: 99.0%

5-bromo-2-methoxybenzoic acid (2476-35-9) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 5-bromo-2-methoxybenzoate (7120-41-4)

Guidance literature:

In Petroleum ether;

Reference yield: 95.0%

5-bromosalicyclic acid (89-55-4) + methyl iodide (74-88-4) → methyl 5-bromo-2-methoxybenzoate (7120-41-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

upstream raw materials:

5-bromo-2-hydroxy-benzoic acid methyl ester

methyl iodide

5-bromosalicyclic acid

methanol

Downstream raw materials:

2-(5-bromo-2-methoxyphenyl)propan-2-ol

2-[5-(4-{[2-(4-fluorophenyl)ethyl]amino}-6-methoxy-1,3,5-triazin-2-yl)-2-methoxyphenyl]propan-2-ol

4-{[2-(4-fluorophenyl)ethyl]amino}-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-ol

tert-butyl [2-(4-fluorophenyl)ethyl]{4-hydroxy-6-[3-(1-hydroxy-1-methylethyl)-4-methoxyphenyl]-1,3,5-triazin-2-yl}carbamate

Refernces

• 1、 Forse, Alexander C.,Kim, Eugene J.,Lee, Jung-Hoon,Long, Jeffrey R.,Mao, Victor Y.,McGuirk, C. Michael,Milner, Phillip J.,Neaton, Jeffrey B.,Porter-Zasada, Leo B.,Reimer, Jeffrey A.,Siegelman, Rebecca L.. "Cooperative Carbon Dioxide Adsorption in Alcoholamine- and Alkoxyalkylamine-Functionalized Metal–Organic Frameworks". supporting information. p. 19468 - 19477. Retrieved 2020/02/11.
• 2、 -. "Sulfonamide compound and medical applications thereof". Paragraph 0067-0070. . Retrieved 2019/02/13.