Dibenzo[c,E]cycloheptene, 2,3,4,7-tetramethoxy-

Base Information

• Chemical Name: Dibenzo[c,E]cycloheptene, 2,3,4,7-tetramethoxy-
• CAS No.: 127825-89-2
• Molecular Formula: C₁₉H₂₀O₄
• Molecular Weight: 312.365
• Mol file: 127825-89-2.mol

Synonyms:Dibenzo[c,E]cycloheptene, 2,3,4,7-tetramethoxy-

Chemical Property of Dibenzo[c,E]cycloheptene, 2,3,4,7-tetramethoxy-

Chemical Property:

• PSA: 36.92000
• LogP: 3.95730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dibenzo[c,E]cycloheptene, 2,3,4,7-tetramethoxy-

There total 11 articles about Dibenzo[c,E]cycloheptene, 2,3,4,7-tetramethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',3',4,4'-tetramethoxy[1,1'-biphenyl]-2-carboxaldehyde (119101-14-3) → 3,9,10,11-tetramethoxy-5H-dibenzo[a,c]cycloheptene (127825-89-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaH / 1.) THF, 0 deg C, 20 min; 2.) THF, room temp., 4 h

2: 91 percent / H₂ / Pd / ethyl acetate; methanol / 10 h / 760 Torr

3: 97 percent / NaOH (20percent aq.) / methanol / 3 h / Heating

4: 68 percent / trifluoroacetic anhydride / trifluoroacetic acid / 10 h / Ambient temperature

5: 84.5 percent / Na-borohydride / methanol / 2 h / Ambient temperature

6: 200 °C / vacuo

With sodium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride; trifluoroacetic anhydride; palladium; In methanol; ethyl acetate; trifluoroacetic acid;

DOI:10.1002/hlca.19890720805

Reference yield:

ethyl 3-(2',3',4,4'-tetramethoxy-1,1'-biphenyl-2-yl)prop-2-enoate (127825-94-9) → 3,9,10,11-tetramethoxy-5H-dibenzo[a,c]cycloheptene (127825-89-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 91 percent / H₂ / Pd / ethyl acetate; methanol / 10 h / 760 Torr

2: 97 percent / NaOH (20percent aq.) / methanol / 3 h / Heating

3: 68 percent / trifluoroacetic anhydride / trifluoroacetic acid / 10 h / Ambient temperature

4: 84.5 percent / Na-borohydride / methanol / 2 h / Ambient temperature

5: 200 °C / vacuo

With sodium hydroxide; sodium tetrahydroborate; hydrogen; trifluoroacetic anhydride; palladium; In methanol; ethyl acetate; trifluoroacetic acid;

DOI:10.1002/hlca.19890720805

Reference yield:

→ 3,9,10,11-tetramethoxy-5H-dibenzo[a,c]cycloheptene (127825-89-2) + 1,2,3,9-tetramethoxy-5H-dibenzocycloheptene (127825-88-1)

Guidance literature:

With phosphorus pentoxide; xylene;

DOI:10.1080/10473289.2001.10464260

upstream raw materials:

6,7-dihydro-1,2,3,9-tetramethoxy-5H-dibenzocyclohepten-5-ol

tetrachloromethane

N-Acetylcolchinol methyl ether

(2,3,4,7-Tetramethoxy-9,10-dihydro-[9]phenanthryl)-methanol

Downstream raw materials:

deaminocolchinol methyl ether