4-Methoxy-3-Methylaniline hydrochloride

Base Information

• Chemical Name: 4-Methoxy-3-Methylaniline hydrochloride
• CAS No.: 1185297-84-0
• Molecular Formula: C₈H₁₁NO*ClH
• Molecular Weight: 173.642
• Hs Code.: 2922299090
• Mol file: 1185297-84-0.mol

Synonyms:

Chemical Property of 4-Methoxy-3-Methylaniline hydrochloride

Chemical Property:

• PSA: 35.25000
• LogP: 2.96900

Purity/Quality:

98%min ^*data from raw suppliers

4-Methoxy-3-methylaniline hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-3-Methylaniline hydrochloride

There total 5 articles about 4-Methoxy-3-Methylaniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(4-methoxy-3-methylphenyl)acetamide (31910-25-5) → 4-methoxy-3-methylaniline hydrochloride (1185297-84-0)

Guidance literature:

With hydrogenchloride; water; In ethanol; for 4h; Reflux;

DOI:10.1002/jhet.561

Reference yield:

4-acetamido-2-methylphenol (16375-90-9) → 4-methoxy-3-methylaniline hydrochloride (1185297-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / 1 h / Reflux

2: hydrogenchloride; water / ethanol / 4 h / Reflux

With hydrogenchloride; water; sodium ethanolate; In ethanol;

DOI:10.1002/jhet.561

Reference yield:

p-nitroso-o-cresol (6971-38-6) → 4-methoxy-3-methylaniline hydrochloride (1185297-84-0)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium hydroxide; hydrogen sulfide / water

2: water / 0.5 h / 60 - 65 °C

3: sodium ethanolate / ethanol / 1 h / Reflux

4: hydrogenchloride; water / ethanol / 4 h / Reflux

With hydrogenchloride; ammonium hydroxide; hydrogen sulfide; water; sodium ethanolate; In ethanol; water;

DOI:10.1002/jhet.561

upstream raw materials:

4-acetamido-2-methylphenol

p-nitroso-o-cresol

4-amino-2-methylphenol

N-(4-methoxy-3-methylphenyl)acetamide

Downstream raw materials:

2-(4-methoxy-3-methylphenyl)hydrazono-5-methylcyclohexanone

Refernces