31910-25-5

Basic information

• Product Name: Acetamide, N-(4-methoxy-3-methylphenyl)-
• CAS NO: 31910-25-5
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol File: 31910-25-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(4-methoxy-3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(4-methoxy-3-methylphenyl)-(31910-25-5)
• EPA Substance Registry System: Acetamide, N-(4-methoxy-3-methylphenyl)-(31910-25-5)

Safety Data

• Hazardous Substances Data: 31910-25-5(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 136-90-3 4-methoxy-3-methylaniline 
• 16375-90-9 4-acetamido-2-methylphenol 
• 77-78-1 dimethyl sulfate 
• 89345-80-2 4-O-Methyl-4-methyl-p-benzoquinol N-acetylimine 
• 27451-21-4 N-hydroxy-N-(p-tolyl)acetamide 
• 75-36-5 acetyl chloride 
• 95-48-7 ortho-cresol 
• 6971-38-6 p-nitroso-o-cresol 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 537-92-8 3-Methylacetanilide 
• 2835-96-3 4-amino-2-methylphenol 
• 50741-92-9 2-methyl-4-nitroanisole 

Downstream Products

• 1295585-45-3 2-(4-methoxy-3-methylphenyl)hydrazono-5-methylcyclohexanone 
• 1185297-84-0 4-methoxy-3-methylaniline hydrochloride 
• 55730-09-1 4-methoxy-5-methyl-2-nitroaniline 
• 13120-77-9 2-methyl-5-nitroanisole 
• 136-90-3 4-methoxy-3-methylaniline 
• 518990-51-7 acetic acid-(4-methoxy-5-methyl-2-nitro-anilide) 
• 344794-49-6 2-chloro-4-methoxy-5-methyl-aniline 

Relevant articles and documents

Selective, Catalytic, and Metal-Free Coupling of Electron-Rich Phenols and Anilides Using Molecular Oxygen as Terminal Oxidant

Selective oxidative homo- and cross-coupling of electron-rich phenols and anilides was developed using nitrosonium tetrafluoroborate as a catalyst. Oxidative coupling of phenols revealed unusual selectivities, which translated into the unprecedented synthesis of inverse Pummerer-type ketones. Mechanistic studies suggest that oxidative coupling of phenols and anilides shares a common pathway via homolytical heteroatom-hydrogen bond cleavage. Nitrosonium salt catalysis was applied for cross-dehydrogenative coupling initiated by generation of heteroatom-centered radicals.

Direct acetoxylation and etherification of anilides using phenyliodine bis(trifluoroacetate)

Treatment of various anilides with 1.5 equiv. of phenyliodine bis(trifluoroacetate) (PIFA) and 1.0 equiv. of BF3·OEt 2 in AcOH at room temperature afforded the corresponding para-acetoxylated products with high regioselectivity. In addition, this reaction could be expanded to the etherification of anilides. In the presence of 2.0 equiv. of PIFA and 2.0 equiv. of BF3·OEt2, the reaction of anilides with alcohols provided the corresponding para-etherified products in good yields. The Royal Society of Chemistry 2011.