2-(4-Aminophenoxymethyl)-2,5,7,8-tetramethyl-4-oxochroman-6-YL acetate

Base Information

Chemical Name:2-(4-Aminophenoxymethyl)-2,5,7,8-tetramethyl-4-oxochroman-6-YL acetate
CAS No.:107188-37-4
Molecular Formula:C22H25NO5
Molecular Weight:369.461
Hs Code.:
DSSTox Substance ID:DTXSID20544850
Mol file:107188-37-4.mol

Synonyms:107188-37-4;2-(4-AMINOPHENOXYMETHYL)-2,5,7,8-TETRAMETHYL-4-OXOCHROMAN-6-YL ACETATE;[2-[(4-aminophenoxy)methyl]-2,5,7,8-tetramethyl-4-oxo-3H-chromen-6-yl] acetate;LHBDZFJPOIRNNI-UHFFFAOYSA-N;SCHEMBL7125937;DTXSID20544850;4-(6-acetoxy-2,5,7,8-tetramethyl-4-oxochroman-2-ylmethoxy)aniline;6-acetoxy-2-(4-aminophenoxymethyl)-2,5,7,8-tetramethylchroman-4-one;2-[(4-Aminophenoxy)methyl]-2,5,7,8-tetramethyl-4-oxo-3,4-dihydro-2H-1-benzopyran-6-yl acetate

Suppliers and Price of 2-(4-Aminophenoxymethyl)-2,5,7,8-tetramethyl-4-oxochroman-6-YL acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 2-(4-Aminophenoxymethyl)-2,5,7,8-tetramethyl-4-oxochroman-6-YL acetate

Chemical Property:

PSA：87.85000
LogP:4.50340
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:383.17327290
Heavy Atom Count:28
Complexity:588

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=C(C2=C1OC(CC2=O)(C)COC3=CC=C(C=C3)N)C)OC(=O)C)C

Technology Process of 2-(4-Aminophenoxymethyl)-2,5,7,8-tetramethyl-4-oxochroman-6-YL acetate

There total 6 articles about 2-(4-Aminophenoxymethyl)-2,5,7,8-tetramethyl-4-oxochroman-6-YL acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 118070-83-0
2,5,7,8-tetramethyl-6-acetoxy-2-(4-nitrophenyloxy)methylchroman

: 107188-37-4
6-acetoxy-2-[(4-aminophenoxy)methyl]-2,5,7,8-tetramethylchromane

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; benzene; for 3h; under 2325.2 - 2850.2 Torr;
DOI:10.1021/jm00122a022

Reference yield:

: 79907-49-6
2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-ol

: 107188-37-4
6-acetoxy-2-[(4-aminophenoxy)methyl]-2,5,7,8-tetramethylchromane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, rt, 1 h, 2.) benzene, rt, 1 h

2: 1.) NaH / 1.) DMSO, benzene, 60 deg C, 20 min, 2.) 60 deg C, 1 h

3: 94 percent / AcOH, 10percent H₂SO₄ / 0.17 h / 60 °C

4: 94 percent / pyridine / 1.) 10 deg C to rt, 2.) 30 deg C, 1 h

5: 98 percent / H₂ / 10percent Pd-C / methanol; benzene / 3 h / 2325.2 - 2850.2 Torr

With pyridine; sulfuric acid; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In methanol; benzene;
DOI:10.1021/jm00122a022

Reference yield:

: 107188-55-6
2-hydroxymethyl-6-methoxymethoxy-2,5,7,8-tetramethylchroman

: 107188-37-4
6-acetoxy-2-[(4-aminophenoxy)methyl]-2,5,7,8-tetramethylchromane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMSO, benzene, 60 deg C, 20 min, 2.) 60 deg C, 1 h

2: 94 percent / AcOH, 10percent H₂SO₄ / 0.17 h / 60 °C

3: 94 percent / pyridine / 1.) 10 deg C to rt, 2.) 30 deg C, 1 h

4: 98 percent / H₂ / 10percent Pd-C / methanol; benzene / 3 h / 2325.2 - 2850.2 Torr

With pyridine; sulfuric acid; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In methanol; benzene;
DOI:10.1021/jm00122a022