RARECHEM AL BA 0176

Base Information

• Chemical Name: RARECHEM AL BA 0176
• CAS No.: 698998-84-4
• Molecular Formula: C9H8BF3O2
• Molecular Weight: 215.968
• Mol file: 698998-84-4.mol

Synonyms:RARECHEM AL BA 0176;trans-2-[3-(Trifluoromethyl)phenyl]vinylboronic acid

Chemical Property of RARECHEM AL BA 0176

Chemical Property:

• Melting Point: 84-89 °C(lit.)
• PSA: 40.46000
• LogP: 1.73060

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-TRIFLUOROMETHYL-PHENYL)-ETHENEBORONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RARECHEM AL BA 0176

There total 1 articles about RARECHEM AL BA 0176 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(E)-4,4,5,5-tetramethyl-2-(3-(trifluoromethyl)styryl)-1,3-dioxa-2-borolane (1073354-88-7) → {(E)-2-[3-(trifluoromethyl)phenyl]vinyl}boronic acid (698998-84-4)

Guidance literature:

With sodium periodate; ammonium acetate; In acetone; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja401840j

Reference yield: 62.0%

{(E)-2-[3-(trifluoromethyl)phenyl]vinyl}boronic acid (698998-84-4) + 3-bromo-6-chloro-imidazo[1,2-b]pyridazine (13526-66-4) → 6-chloro-3-[(E)-2-[3-(trifluoromethyl)phenyl]vinyl]imidazo[1,2-b]pyridazine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 11h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.09.064

Reference yield: 56.0%

{(E)-2-[3-(trifluoromethyl)phenyl]vinyl}boronic acid (698998-84-4) + 4-iodo-3,5-bis(4-methoxyphenyl)isoxazole (258860-15-0) → (E)-4-(3-trifluoromethylstyryl)-3,5-bis(4-methoxyphenyl)isoxazole (1400413-94-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; water; sodium hydrogencarbonate; In 1,2-dimethoxyethane; at 80 ℃; for 19h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.06.097

upstream raw materials:

(E)-4,4,5,5-tetramethyl-2-(3-(trifluoromethyl)styryl)-1,3-dioxa-2-borolane

Downstream raw materials:

C₁₃H₁₆BF₃O₂

(E)-4-(3-trifluoromethylstyryl)-3,5-bis(4-methoxyphenyl)isoxazole

(E)-o-tolyl(4-(trifluoromethyl)styryl)-λ³-iodanyl trifluoromethanesulfonate

(3Z,5E)-4-ethyl-6-(4-(trifluoromethyl)phenyl)hexa-3,5-dien-3-yl trifluoromethanesulfonate