4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)-

Base Information

Chemical Name:4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)-
CAS No.:256498-66-5
Molecular Formula:C21H21FN8O
Molecular Weight:420.44
Hs Code.:
UNII:323T2C09SG
DSSTox Substance ID:DTXSID10180342
Nikkaji Number:J1.711.752A
Wikidata:Q27256130
ChEMBL ID:CHEMBL1916024
Mol file:256498-66-5.mol

Synonyms:BAY 41-8543

Suppliers and Price of 4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BAY 41-8543
5mg
$ 440.00

Tocris
BAY 41-8543 ≥98%(HPLC)
50
$ 963.00

Tocris
BAY 41-8543 ≥98%(HPLC)
10
$ 229.00

Sigma-Aldrich
BAY 41-8543 ≥98% (HPLC)
5MG
$ 103.00

Sigma-Aldrich
BAY 41-8543 ≥98% (HPLC)
25MG
$ 414.00

Crysdot
BAY 41-8543 97%
100mg
$ 1420.00

ChemScene
BAY 41-8543
100mg
$ 1160.00

Chemenu
2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine 95%+
100mg
$ 1740.00

Cayman Chemical
BAY 41-8543 ≥98%
25mg
$ 965.00

Cayman Chemical
BAY 41-8543 ≥98%
10mg
$ 442.00

Total 7 raw suppliers

Chemical Property of 4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)-

Chemical Property:

Boiling Point:599.7±50.0 °C(Predicted)
PKA:5.18±0.10(Predicted)
PSA：121.00000
Density:1.55±0.1 g/cm3(Predicted)
LogP:3.30410
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:420.18223549
Heavy Atom Count:31
Complexity:584

Purity/Quality:

97% ^*data from raw suppliers

BAY 41-8543 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1C2=C(N=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F)N
Uses BAY 41-8543, is a Guanylyl cyclase (sGC) stimulator, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold. BAY 41-8543 reduces pulmonary vascular resistance and protects right ventricular (RV)function. It also inhibits collagen-induced platelet aggregation, and promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. It has also shown Antihypertensive activity.

Technology Process of 4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)-

There total 1 articles about 4,6-Pyrimidinediamine, 2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-(4-morpholinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.1%