4432-41-1

Basic information

• Product Name: Propanedinitrile, 4-morpholinyl- (9CI)
• Synonyms: Propanedinitrile, 4-morpholinyl- (9CI)
• CAS NO: 4432-41-1
• Molecular Formula: C₇H₉N₃O
• Molecular Weight: 0
• Mol File: 4432-41-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanedinitrile, 4-morpholinyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, 4-morpholinyl- (9CI)(4432-41-1)
• EPA Substance Registry System: Propanedinitrile, 4-morpholinyl- (9CI)(4432-41-1)

Safety Data

• Hazardous Substances Data: 4432-41-1(Hazardous Substances Data)

Upstream product

• 6082-48-0 diethyl 2-morpholinopropanedioate 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 256498-66-5 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine 

Relevant articles and documents

Discovery of Novel Pyrazolo[3,4- b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension

Current pulmonary arterial hypertension (PAH) therapeutic strategies mainly focus on vascular relaxation with less emphasis on vascular remodeling, which results in poor prognosis. Hence, dual pathway regulators with vasodilation effect via soluble guanylate cyclase (sGC) stimulation and vascular remodeling regulation effect by AMP-activated protein kinase (AMPK) inhibition provide more advantages and potentialities. Herein, we designed and synthesized a series of novel pyrazolo[3,4-b] pyridine derivatives based on sGC stimulator and AMPK inhibitor scaffolds. In vitro, 2 exhibited moderate vasodilation activity and higher proliferation and migration suppressive effects compared to riociguat. In vivo, 2 significantly decreased right ventricular systolic pressure (RVSP), attenuated pulmonary artery medial thickness (PAMT), and right ventricular hypertrophy (RVH) in hypoxia-induced PAH rat models (i.g.). Given the unique advantages of significant vascular remodeling inhibition and moderate vascular relaxation based on the dual pathway regulation, we proposed 2 as a promising lead for anti-PAH drug discovery.

The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles

A mild and efficient method for the synthesis of cyanoformamides from N,N-disubstituted aminomalononitriles with CsF as the promoter has been developed. This method features a wide substrate scope and high reaction efficiency, and will facilitate corresponding cyanoformamide-based biological studies and synthetic methodology development.

Synthetic method for N,N-disubstituted amino-malononitrile compounds

The invention relates to a synthetic method for N,N-disubstituted amino-malononitrile compounds. The method has a general reaction formula as described in the specification. According to the synthetic method, amino-substituted malononitrile is formed from N,N-disubstituted formamide and trimethylsilyl cyanide (TMSCN) under the action of a metal copper catalyst. The method provided by the invention has the advantages of easily available raw materials, mild reaction conditions and no need of protection of inert gas; and a concise and highly-efficient preparation method is provided for amino-substituted malononitrile compounds.