7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride

Base Information

• Chemical Name: 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride
• CAS No.: 321435-99-8
• Molecular Formula: C10H13BrClN
• Molecular Weight: 226.116
• Hs Code.: 2933990090
• Mol file: 321435-99-8.mol

Synonyms:7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride;7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine

Chemical Property of 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride

Chemical Property:

• Boiling Point: 318.8±31.0 °C(Predicted)
• PKA: 4.40±0.20(Predicted)
• PSA: 12.03000
• Density: 1.360±0.06 g/cm3(Predicted)
• LogP: 4.13730

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride

There total 13 articles about 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ 7-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (321435-99-8)

Guidance literature:

Reference yield: 65.0%

2,3,4,5-tetrahydro-1Hbenzo[b]azepine (1701-57-1) → 7-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (321435-99-8)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

DOI:10.1021/acs.jmedchem.0c02210

Reference yield: 47.2%

7-bromo-3,4-dihydro-1H-1-benzazepine-2,5-dione (137046-58-3) → 7-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (321435-99-8)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 65 ℃; for 5h;

upstream raw materials:

7-bromo-3,4-dihydro-1H-1-benzazepine-2,5-dione

carbon monoxide

2-allyl-4-bromoaniline

2-ethoxycarbonylaniline