4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Base Information

Chemical Name:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
CAS No.:29925-17-5
Deprecated CAS:34185-37-0
Molecular Formula:C₁₅H₂₂N₂O₃
Molecular Weight:278.351
Hs Code.:2933990090
European Community (EC) Number:636-902-1
UNII:DIW6F13QW2
DSSTox Substance ID:DTXSID80952376
Nikkaji Number:J23.564D
Wikidata:Q27893950
Pharos Ligand ID:3AMMWC9526YA
ChEMBL ID:CHEMBL18701
Mol file:29925-17-5.mol

Synonyms:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone;Ro 1724;Ro 20 1724;Ro 20-1724;Ro 201724

Suppliers and Price of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Ro 20-1724
50mg
$ 310.00

TRC
Ro-20-1724
5mg
$ 85.00

Tocris
Ro-20-1724 ≥99%(HPLC)
50
$ 87.00

Sigma-Aldrich
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid
500mg
$ 428.00

Sigma-Aldrich
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid
100mg
$ 93.10

Sigma-Aldrich
Ro-20-1724
100mg
$ 89.80

CSNpharm
Ro-20-1724
100mg
$ 88.00

CSNpharm
Ro-20-1724
250mg
$ 158.00

Cayman Chemical
Ro 20-1724 ≥95%
100mg
$ 70.00

Cayman Chemical
Ro 20-1724 ≥95%
50mg
$ 40.00

Total 18 raw suppliers

Chemical Property of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Chemical Property:

Appearance/Colour:solid
Vapor Pressure:1.62E-09mmHg at 25°C
Refractive Index:1.521
Boiling Point:483.8 °C at 760 mmHg
Flash Point:246.4 °C
PSA：59.59000
Density:1.099 g/cm³
LogP:2.75560
Storage Temp.:Store at RT
Solubility.:ethanol: 7 mg/mL
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:278.16304257
Heavy Atom Count:20
Complexity:312

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ro 20-1724 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC
Description RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
Uses Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells. Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.

Technology Process of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

There total 5 articles about 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 124-38-9,18923-20-1
carbon dioxide

: 2-azido-3-(3-butoxy-4-methoxyphenyl)propan-1-amine

: 29925-17-5,34185-37-0
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidone

Guidance literature:: With trimethylphosphane; In 2-methyltetrahydrofuran; acetonitrile; at 20 ℃; for 0.5h; Schlenk technique;
DOI:10.1021/jacs.0c11025

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 29925-17-5,34185-37-0
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

2.1: magnesium; iodine / tetrahydrofuran / 5 h / 50 °C / Schlenk technique; Inert atmosphere

2.2: 50 °C / Schlenk technique; Inert atmosphere

3.1: O-pivaloylhydroxylamine trifluoromethanesulfonate salt; iron(II) triflate; sodium azide / methanol / 16 h / 20 °C

4.1: trimethylphosphane / acetonitrile; 2-methyltetrahydrofuran / 0.5 h / 20 °C / Schlenk technique

With iron(II) triflate; sodium azide; O-pivaloylhydroxylamine trifluoromethanesulfonate salt; iodine; potassium carbonate; magnesium; trimethylphosphane; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jacs.0c11025

Reference yield:

: 4-bromo-2-butoxy-1-methoxybenzene

: 29925-17-5,34185-37-0
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidone

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 5 h / 50 °C / Schlenk technique; Inert atmosphere

1.2: 50 °C / Schlenk technique; Inert atmosphere

2.1: O-pivaloylhydroxylamine trifluoromethanesulfonate salt; iron(II) triflate; sodium azide / methanol / 16 h / 20 °C

3.1: trimethylphosphane / acetonitrile; 2-methyltetrahydrofuran / 0.5 h / 20 °C / Schlenk technique

With iron(II) triflate; sodium azide; O-pivaloylhydroxylamine trifluoromethanesulfonate salt; iodine; magnesium; trimethylphosphane; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jacs.0c11025